| Identification | Back Directory | [Name]
4-N[2(4-HYDROXYPYRIMIDINYL)]AMINOBENZONITRILE | [CAS]
189956-45-4 | [Synonyms]
Rilpivirine Lactam Impurity
4-((4-Oxo-1,4-dihydropyrimidin-2-yl)
4-N[2(4-HYDROXYPYRIMIDINYL)]AMINOBENZONITRILE
4-[(4-Hydroxy-pyrimidin-2-yl)amino]-benzonitr
4-[(4-Hydroxy-2-pyrimidinyl)amino]benzonitrile
4-[(6-oxo-1H-pyrimidin-2-yl)amino]benzonitrile
4-(6-Oxo-1,6-dihydropyrimidin-2-ylamino)benzonitrile
4-((4-Oxo-1,4-dihydropyriMidin-2-yl)aMino)benzonitrile
4-[(1,4-Dihydro-4-oxo-2-pyrimidinyl)amino]benzonitrile
Benzonitrile, 4-[(1,4-dihydro-4-oxo-2-pyriMidinyl)aMino]-
4-((4-Oxo-1,4-dihydropyriMidin-2-yl)aMino)benzonitrile ISO 9001：2015 REACH
4-[(4-hydroxy-2-pyrimidinyl)amino]benzonitrile HCLQ: What is
4-[(4-hydroxy-2-pyrimidinyl)amino]benzonitrile HCL Q: What is the CAS Number of
4-[(4-hydroxy-2-pyrimidinyl)amino]benzonitrile HCL Q: What is the storage condition of
4-[(4-hydroxy-2-pyrimidinyl)amino]benzonitrile HCL Q: What are the applications of
4-[(4-hydroxy-2-pyrimidinyl)amino]benzonitrile HCL | [EINECS(EC#)]
606-195-4 | [Molecular Formula]
C11H8N4O | [MDL Number]
MFCD08443716 | [MOL File]
189956-45-4.mol | [Molecular Weight]
212.21 |
| Questions And Answer | Back Directory | [Synthesis]
Weigh 3 g (21 mmol) of 2-(methylthio)pyrimidin-4(3H)-one and 2.99 g (25 mmol) of 4-aminobenzonitrile into a 50 mL round-bottom flask. Under nitrogen protection, slowly heat to 180 °C and react for 8 h. After cooling, add 20 mL of acetonitrile and sonicate. Filter, wash the filter cake with acetonitrile, and TLC analysis showed no 4-aminobenzonitrile residue. Dry the filter cake to obtain a pale yellow solid, which is 4-((4-Oxo-1,4-dihydropyriMidin-2-yl)aMino)benzonitrile, with a yield of 73.6%. 
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| Chemical Properties | Back Directory | [Melting point ]
>300°C | [density ]
1.31±0.1 g/cm3(Predicted) | [vapor pressure ]
0-0Pa at 20-25℃ | [storage temp. ]
2-8°C | [solubility ]
DMSO (Slightly), Methanol (Slightly) | [form ]
Solid | [pka]
8.66±0.40(Predicted) | [color ]
Pale Brown to Brown | [LogP]
0.9 at pH6.6 | [CAS DataBase Reference]
189956-45-4 |
| Hazard Information | Back Directory | [Chemical Properties]
Light Brown Solid | [Uses]
4-N[2(4-hydroxypyriMidinyl)]aMinobenzonitrile is used in the preparation of 2-naphthyl substituted diarylpyrimidines (DAPY) analogues.
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