| Identification | Back Directory | [Name]
KIN1408 | [CAS]
1903800-11-2 | [Synonyms]
KIN1408
KIN-1408
(KIN-1408
KIN1408 >=98% (HPLC)
8-Quinolinol, 7-[[4-(difluoromethoxy)phenyl][(5-methoxy-2-benzothiazolyl)amino]methyl]-
7-((4-(difluoromethoxy)phenyl)((5-methoxybenzo[d]thiazol-2-yl)amino)methyl)quinolin-8-ol)
KIN-1408;KIN 1408;7-((4-(DIFLUOROMETHOXY)PHENYL)((5-METHOXYBENZO[D]THIAZOL-2-YL)AMINO)METHYL)QUINOLIN-8-OL | [Molecular Formula]
C25H19F2N3O3S | [MOL File]
1903800-11-2.mol | [Molecular Weight]
479.5 |
| Chemical Properties | Back Directory | [Boiling point ]
675.6±65.0 °C(Predicted) | [density ]
1.430±0.06 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
DMSO:34.5(Max Conc. mg/mL);71.95(Max Conc. mM) | [form ]
A solid | [pka]
4.22±0.50(Predicted) | [color ]
Light yellow to yellow |
| Hazard Information | Back Directory | [Description]
KIN1408 is a small molecule activator of the RIG-1-like receptor (RLR) pathway that has antiviral activity. It induces interferon regulatory factor 3 (IRF3) activation and translocation into the nucleus in a concentration-dependent manner in HEK293 cells without inducing cellular toxicity. KIN1408 induces expression of the innate immune genes MDA5, RIG-1, Mx1, IRF7, and IFIT1 in THP-1 cells stimulated with phorbol 12-myristate 12-acetate (PMA; ). It exhibits concentration-dependent broad-spectrum antiviral activity against dengue virus 2 as well as the influenza A, Ebola, Nipah, and Lassa viruses. | [Uses]
KIN1408 is an agonist of the RIG-1-like receptor (RLR) pathway and exhibits a broad-spectrum antiviral activity. KIN1408 exhibits activity against HCV, influenza A, dengue virus 2, Ebola, Nipah, and Lassa viruses[1][2]. | [References]
[1] Green RR, et al. Transcriptional analysis of antiviral small molecule therapeutics as agonists of the RLR pathway. Genom Data. 2016 Feb 1;7:290-2. DOI:10.1016/j.gdata.2016.01.020
[2] Sowmya Pattabhi, et al. Targeting Innate Immunity for Antiviral Therapy through Small Molecule Agonists of the RLR Pathway. J Virol. 2015 Dec 16;90(5):2372-87. DOI:10.1128/JVI.02202-15 |
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| Company Name: |
Energy Chemical
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| Tel: |
021-58432009 400-005-6266 |
| Website: |
http://www.energy-chemical.com |
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