| Identification | Back Directory | [Name]
LMPTP inhibitor1 | [CAS]
1908414-82-3 | [Synonyms]
CS-2789
MDK4823
MDK-4823
MDK 4823
LMPTP-IN23
LMPTP-IN-23
LMPTP-IN 23
INVIVO-4823
LMPTP inhibitor1
MLS-0322825 Cmpd 23
LMW-PTP Inhibitor I
LMPTP INHIBITOR COMPOUND 1
LMPTP inhibitor-Compound 23
NN-Diethyl-4-[4-[[3-(1-piperidinyl)propyl]amino]-2-quinolinyl]benzamide | [Molecular Formula]
C28H36N4O | [MOL File]
1908414-82-3.mol | [Molecular Weight]
444.61 |
| Chemical Properties | Back Directory | [Boiling point ]
657.7±55.0 °C(Predicted) | [density ]
1.121±0.06 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
DMF: 20mg/mL,DMSO: 10mg/mL,Ethanol: 15mg/mL,PBS (pH 7.2): 3mg/mL | [pka]
9.48±0.10(Predicted) |
| Hazard Information | Back Directory | [Description]
LMW-PTP inhibitor I is an inhibitor of low molecular weight phosphotyrosine protein phosphatase A (LMW-PTPA; IC50 = 0.8 μM). It is selective for LMW-PTPA over a panel of 15 protein tyrosine phosphatases but does inhibit LMW-PTPB activity by greater than 50% at 40 μM. LMW-PTP inhibitor I increases insulin-induced insulin receptor phosphorylation in HepG2 cells when used at a concentration of 10 μM. It improves glucose tolerance and decreases fasting plasma insulin levels in a mouse model of diet-induced obesity when administered at a dose of 50 mg/kg per day. | [Uses]
LMPTP inhibitor 1 is a selective inhibitor of low molecular weight protein tyrosine phosphatase (LMPTP), with an IC50 of 0.8 μM LMPTP-A. | [in vivo]
LMPTP inhibitor 1 is orally bioavailable, and results in appr 680 nM mean serum concentration after treatment of 0.03% w/w, while treatment with 0.05% w/w results in >3 μM; also reverses diabetes in obese mice. LMPTP inhibitor 1 (0.05% w/w) inhibits LMPTP activity, significantly improves glucose tolerance and decreases fasting insulin levels of diabetic DIO mice, without affecting body weight[1]. | [References]
[1] Stanford SM1, et al. Diabetes reversal by inhibition of the low-molecular-weight tyrosine phosphatase. Nat Chem Biol. 2017 Jun;13(6):624-632. DOI:10.1038/nchembio.2344 |
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| Company Name: |
Cckinase, Inc.
|
| Tel: |
+1 (732)236-3202 |
| Website: |
www.cckinase.com |
| Company Name: |
InvivoChem
|
| Tel: |
13549236410 |
| Website: |
https://www.invivochem.cn/ |
|