| Identification | Back Directory | [Name]
Ethanone, 1-[5-methyl-8-(1-methylethyl)-2-[[4-(1-piperazinyl)phenyl]amino]imidazo[1',2':1,6]pyrido[2,3-d]pyrimidin-6-yl]- | [CAS]
1908454-70-5 | [Synonyms]
Ethanone, 1-[5-methyl-8-(1-methylethyl)-2-[[4-(1-piperazinyl)phenyl]amino]imidazo[1',2':1,6]pyrido[2,3-d]pyrimidin-6-yl]- | [Molecular Formula]
C25H29N7O | [MOL File]
1908454-70-5.mol | [Molecular Weight]
443.54 |
| Hazard Information | Back Directory | [Uses]
As a cdk4/6 inhibitor. Compounds 10B and 10C showed low nanomolar activity, ideal antiproliferative activity, excellent metabolic properties and acceptable pharmacokinetics on cdk4/6. | [References]
[1] Shi C,et al. Discovery of a novel series of imidazo[1',2':1,6]pyrido[2,3-d]pyrimidin derivatives as potent cyclin-dependent kinase 4/6 inhibitors. Eur J Med Chem. 2020 May 1;193:112239. DOI:10.1016/j.ejmech.2020.112239 |
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