| Identification | Back Directory | [Name]
RWJ 63556 | [CAS]
190967-35-2 | [Synonyms]
RWJ 63556
Methanesulfonamide, N-[5-(4-fluorophenoxy)-2-thienyl]- | [Molecular Formula]
C11H10FNO3S2 | [MDL Number]
MFCD00952930 | [MOL File]
190967-35-2.mol | [Molecular Weight]
287.33 |
| Chemical Properties | Back Directory | [Boiling point ]
403.4±55.0 °C(Predicted) | [density ]
1.479±0.06 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
Soluble in DMSO | [form ]
Solid | [pka]
8.60±0.10(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Uses]
RWJ 63556 is an orally active COX-2 selective/5-lipoxygenase inhibitor, with anti-inflammatory activities. | [in vivo]
RWJ 63556 (1?mg/kg, i.v.) significantly inhibits the development of SP-induced oedema[2]. | [IC 50]
COX-2; 5-Lipoxygenase | [References]
[1] Kirchner T, et al. Evaluation of the antiinflammatory activity of a dual cyclooxygenase-2 selective/5-lipoxygenase inhibitor, RWJ 63556, in a canine model of inflammation. J Pharmacol Exp Ther. 1997 Aug;282(2):1094-101. PMID:9262379
[2] Le Filliatre G, et al. Cyclo-oxygenase and lipoxygenase pathways in mast cell dependent-neurogenic inflammation induced by electrical stimulation of the rat saphenous nerve. Br J Pharmacol. 2001 Apr;132(7):1581-9. DOI:10.1038/sj.bjp.0703950 |
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cjbscvictory
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| Tel: |
13348960310 |
| Website: |
https://www.weikeqi-biotech.com/ |
| Company Name: |
MedChemExpress
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021-58955995 |
| Website: |
www.medchemexpress.com |
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