| Identification | Back Directory | [Name]
PENTANEDIOIC-2,2,4,4-D4 ACID | [CAS]
19136-99-3 | [Synonyms]
Glutaric-d4 Acid
GLUTARIC ACID (2,2,4,4-D4)
PENTANEDIOIC-2,2,4,4-D4 ACID
PENTANEDIOIC ACID (2,2,4,4-D4)
2,2,4,4-tetradeuterio-pentanedioic acid | [Molecular Formula]
C5H8O4 | [MDL Number]
MFCD00209727 | [MOL File]
19136-99-3.mol | [Molecular Weight]
132.12 |
| Chemical Properties | Back Directory | [Melting point ]
94-96 °C | [storage temp. ]
Refrigerator | [solubility ]
DMSO (Slightly), Methanol (Slightly) | [form ]
Solid | [color ]
White to Off-White | [CAS Number Unlabeled]
110-94-1 |
| Hazard Information | Back Directory | [Uses]
Glutaric acid-d4 is the deuterium labeled Glutaric acid. Glutaric acid, C5 dicarboxylic acid, is an intermediate during the catabolic pathways of lysine and tryptophan. Glutaric acid affects pericyte contractility and migration. Glutaric acid is an indicator of glutaric aciduria type I[1][2][3]. | [References]
[1] Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. DOI:10.1177/1060028018797110
[2] Yang SY, et, al. Production of glutaric acid from 5-aminovaleric acid by robust whole-cell immobilized with polyvinyl alcohol and polyethylene glycol. Enzyme Microb Technol. 2019 Sep;128:72-78. DOI:10.1016/j.enzmictec.2019.05.003
[3] Boy N, et, al. Proposed recommendations for diagnosing and managing individuals with glutaric aciduria type I: second revision. J Inherit Metab Dis. 2017 Jan;40(1):75-101. DOI:10.1007/s10545-016-9999-9
[4] Isasi E, et, al. Glutaric Acid Affects Pericyte Contractility and Migration: Possible Implications for GA-I Pathogenesis. Mol Neurobiol. 2019 Nov;56(11):7694-7707. DOI:10.1007/s12035-019-1620-4 |
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