| Identification | Back Directory | [Name]
3,9,10-trimethoxy-5,6-dihydroisoquinolino[2,1-b]isoquinolin-7-ium-2-ol chloride | [CAS]
1916-10-5 | [Synonyms]
Columbamine chloride
3,9,10-trimethoxy-5,6-dihydroisoquinolino[2,1-b]isoquinolin-7-ium-2-ol chloride | [Molecular Formula]
C20H20ClNO4 | [MOL File]
1916-10-5.mol | [Molecular Weight]
373.83 |
| Hazard Information | Back Directory | [Uses]
food and beverages
pharmaceutical | [in vivo]
Columbamine (5-20 mg/kg; 23 days) significantly decreases the tumor volumes in a dose-dependent manner in HCT116 xenograft mice model[4].
| Animal Model: | Six-weeks-old male BALB/c nude mice (subcutaneously injected with HCT116 and control cells on the opposite flanks of the same mouse)[4] | | Dosage: | 5, 10, 20 mg/kg | | Administration: | Administered to experimental mice for 23 days | | Result: | Decreased the tumor volumes in a dose-dependent manner. |
| [IC 50]
CYP3A4: 30.6 μM (IC50) |
|
| Company Name: |
Merck KGaA
|
| Tel: |
21-20338288 |
| Website: |
www.sigmaaldrich.cn |
|