| Identification | Back Directory | [Name]
3-(5-Amino-1-oxo-isoindolin-2-yl)piperidine-2,6-dione | [CAS]
191732-70-4 | [Synonyms]
C5 Lenalidomide
3-(5-Amino-1-oxo-isoindolin-2-yl)piperidine-2,6-dione
3-(5-amino-1-oxo-2,3-dihydro-1H-isoindol-2-yl)piperidine-2,6-dione
2,6-Piperidinedione, 3-(5-amino-1,3-dihydro-1-oxo-2H-isoindol-2-yl)- | [Molecular Formula]
C13H13N3O3 | [MOL File]
191732-70-4.mol | [Molecular Weight]
259.26 |
| Chemical Properties | Back Directory | [Boiling point ]
634.5±55.0 °C(Predicted) | [density ]
1.460±0.06 g/cm3(Predicted) | [storage temp. ]
2-8°C | [form ]
Solid | [pka]
10.83±0.40(Predicted) | [color ]
Off-white to gray | [InChI]
InChI=1S/C13H13N3O3/c14-8-1-2-9-7(5-8)6-16(13(9)19)10-3-4-11(17)15-12(10)18/h1-2,5,10H,3-4,6,14H2,(H,15,17,18) | [InChIKey]
WLUIQUZGNPAKRL-UHFFFAOYSA-N | [SMILES]
N1C(=O)CCC(N2CC3=C(C2=O)C=CC(N)=C3)C1=O |
| Hazard Information | Back Directory | [Description]
3-(5-Amino-1-oxoisoindolin-2-yl)piperidine-2,6-dione is a lenalidomide analog that can be useful in PROTAC research. | [Uses]
C5 Lenalidomide (Lenalidomide 5'-amine) is a thalidomide analog and is a potent inhibitor of TNF-alpha production (IC50=100 μM in LPS stimulated human PBMC)[1]. | [reaction suitability]
reagent type: ligand | [storage]
Store at -20°C | [References]
[1] G W Muller, et al. Amino-substituted thalidomide analogs: potent inhibitors of TNF-alpha production. Bioorg Med Chem Lett. 1999 Jun 7;9(11):1625-30. DOI:10.1016/s0960-894x(99)00250-4 |
|
| Company Name: |
ChemShuttle, Inc. Gold
|
| Tel: |
0510-83588313-811 18800520310 |
| Website: |
https://www.jiehuapharma.com/ |
|