| Identification | Back Directory | [Name]
RL648_81 | [CAS]
1919050-87-5 | [Synonyms]
RL648_81
RL648_81 >=98% (HPLC)
ethyl N-[2-amino-3-fluoro-4-[[4-(trifluoromethyl)phenyl]methylamino]phenyl]carbamate | [Molecular Formula]
C17H17F4N3O2 | [MDL Number]
MFCD30480927 | [MOL File]
1919050-87-5.mol | [Molecular Weight]
371.33 |
| Chemical Properties | Back Directory | [Boiling point ]
412.8±45.0 °C(Predicted) | [density ]
1.398±0.06 g/cm3(Predicted) | [storage temp. ]
room temp | [solubility ]
DMSO: 25mg/mL, clear | [form ]
Solid | [pka]
12.32±0.70(Predicted) | [color ]
Off-white to light yellow | [InChI]
1S/C17H17F4N3O2/c1-2-26-16(25)24-13-8-7-12(14(18)15(13)22)23-9-10-3-5-11(6-4-10)17(19,20)21/h3-8,23H,2,9,22H2,1H3,(H,24,25) | [InChIKey]
MVSMZQRRMPUGHI-UHFFFAOYSA-N | [SMILES]
NC1=C(NC(OCC)=O)C=CC(NCC2=CC=C(C(F)(F)F)C=C2)=C1F |
| Hazard Information | Back Directory | [Description]
RL648_81 is a novel potent and selective activator of KCNQ2/3 channels. | [Uses]
RL648_81 is a specific KQT-like subfamily 2/3 (KCNQ2/3) activator with an EC50 of 190 nM. RL648_81 robustly shifts the V1/2 of KCNQ2/3 channels towards hyperpolarized potentials.RL648_81 does not shift the V1/2 of either KCNQ4 or KCNQ5.RL648_81 has?the?potential?for?neurologic disorders associated with neuronal hyperexcitability research[1]. | [References]
[1] Manoj Kumar, et al. Synthesis and Evaluation of Potent KCNQ2/3-Specific Channel Activators. Mol Pharmacol. 2016 Jun;89(6):667-77. DOI:10.1124/mol.115.103200 |
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| Company Name: |
Energy Chemical
|
| Tel: |
021-58432009 400-005-6266 |
| Website: |
http://www.energy-chemical.com |
| Company Name: |
Merck KGaA
|
| Tel: |
21-20338288 |
| Website: |
www.sigmaaldrich.cn |
| Company Name: |
Biorbyt Ltd.
|
| Tel: |
+44 (0)1223 859 353 |
| Website: |
http://www.biorbyt.com |
|