| Identification | Back Directory | [Name]
Tipifarnib (S enantioMer) | [CAS]
192185-71-0 | [Synonyms]
Tipifarnib S
(S)-(-)-R-115777
IND-58359 S enantiomer
Tipifarnib (S enantioMer)
Tipifarnib (IND-58359) S enantiomer
(S)-(-)-R-115777;IND-58359 S ENANTIOMER
6-[(S)-amino-(4-chlorophenyl)-(3-methylimidazol-4-yl)methyl]-4-(3-chlorophenyl)-1-methylquinolin-2-one
2(1H)-Quinolinone, 6-[(S)-amino(4-chlorophenyl)(1-methyl-1H-imidazol-5-yl)methyl]-4-(3-chlorophenyl)-1-methyl- | [Molecular Formula]
C27H22Cl2N4O | [MDL Number]
MFCD09837802 | [MOL File]
192185-71-0.mol | [Molecular Weight]
489.4 |
| Chemical Properties | Back Directory | [Boiling point ]
681.7±55.0 °C(Predicted) | [density ]
1.33±0.1 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
DMSO: 10 mg/ml; Methanol: 5 mg/ml | [form ]
A crystalline solid | [pka]
7.20±0.10(Predicted) | [color ]
White to light yellow |
| Hazard Information | Back Directory | [Uses]
Tipifarnib S enantiomer is the S-enantiomer of Tipifarnib. Tipifarnib is a potent and specific farnesyltransferase (FTase) inhibitor with IC50 of 0.6 nM. Tipifarnib S enantiomer is the less active isomer. | [Definition]
ChEBI: 6-[(S)-amino-(4-chlorophenyl)-(3-methyl-4-imidazolyl)methyl]-4-(3-chlorophenyl)-1-methyl-2-quinolinone is a diarylheptanoid. | [References]
[1] Kraus JM, et al. Rational modification of a candidate cancer drug for use against Chagas disease. J Med Chem. 2009 Mar 26;52(6):1639-47. DOI:10.1021/jm801313t |
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