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1924596-31-5

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1924596-31-5 Structure

1924596-31-5 Structure
IdentificationBack Directory
[Name]

Mal-amido-PEG8-TFP ester
[CAS]

1924596-31-5
[Synonyms]

Mal-NH-PEG8-TFP
Mal-amido-PEG8-TFP ester
4,7,10,13,16,19,22,25-Octaoxa-28-azahentriacontanoic acid, 31-(2,5-dihydro-2,5-dioxo-1H-pyrrol-1-yl)-29-oxo-, 2,3,5,6-tetrafluorophenyl ester
[Molecular Formula]

C32H44F4N2O13
[MDL Number]

MFCD28505514
[MOL File]

1924596-31-5.mol
[Molecular Weight]

740.69
Chemical PropertiesBack Directory
[Boiling point ]

780.6±60.0 °C(Predicted)
[density ]

1.292±0.06 g/cm3(Predicted)
[pka]

15.01±0.46(Predicted)
Hazard InformationBack Directory
[Description]

Mal-amido-PEG8-TFP ester is PEG linker containing a maleimide and TFP ester end group. Maleimide groups are reactive with thiols between pH 6.5 and 7.5. The TFP ester can react with primary amine groups and is also less susceptible to undergo hydrolysis compared to NHS ester. The hydrophilic PEG chains increase the water solubility of a compound in aqueous media. Longer PEG chains have improved water solubility relative to shorter PEG chains.
[Uses]

Mal-amido-PEG8-TFP ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
[IC 50]

PEGs
[References]

[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005
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