| Identification | Back Directory | [Name]
Telomycin | [CAS]
19246-24-3 | [Synonyms]
A-128
Telomycin
Nsc235069
Antibiotic 128
A 128-HYP, A 128-OP
18H-Dipyrrolo[2,1-C:2',1'-o][1,4,7,10,13,16,19,22,25]oxaoctaazacyclooctacosine
N-(L-βAsp-L-Ser-)Cyclo(L-Thr*-L-aThr-L-Ala-Gly-L-t3Hyp-3-(1H-indole-3-yl)Dha-β-methyl-L-Trp-4,4-dimethyl-L-aThr-L-c3Hyp-)
L-Proline, L-.beta.-aspartyl-L-seryl-L-threonyl-L-allothreonyl-L-alanylglycyl-trans-3-hydroxy-L-prolyl-erythro-3-hydroxy-L-leucyl-.beta.-methyl-L-tryptophyl-.alpha.,.beta.-didehydro-L-tryptophyl-cis-3-hydroxy-, .beta.1-lactone | [EINECS(EC#)]
242-913-9 | [Molecular Formula]
C59H77N13O19 | [MDL Number]
MFCD01682741 | [MOL File]
19246-24-3.mol | [Molecular Weight]
1272.33 |
| Chemical Properties | Back Directory | [alpha ]
D28 -133° (c = 1 in 2:1 methanol-water) | [Boiling point ]
850.94°C (rough estimate) | [density ]
1.1263 (rough estimate) | [refractive index ]
1.6700 (estimate) | [storage temp. ]
Store at -20°C | [solubility ]
DMF: soluble; DMSO: soluble; Ethanol: soluble; Methanol: soluble; Water: slightly soluble | [form ]
A solid | [pka]
2.41±0.10(Predicted) | [Sequence]
{Bas}-Ser-Thr-Thr-Ala-Gly-{Pro(3S-OH)}-{Trp(α,β-Didehydro)}-{Trp(β-Me)}-{Leu(3S-OH)}-{Pro(3R-OH)} (lactone bridge: Thr3-Pro11) |
| Hazard Information | Back Directory | [Uses]
Telomycin is a complex, high molecular weight depsipeptide discovered in 1958. The structure was not solved until 1968. Telomycin possesses potent and highly selective activity against Gram positive bacteria in vitro and in vivo when given by intramuscular administration. Telomycin is poorly absorbed after oral administration. Despite its structural novelty, telomycin has received little attention. | [Uses]
Telomycin is a complex, high molecular weight depsipeptide discovered in 1958. The structure was subsequently solved in 1968. Telomycin possesses potent and highly selective activity against Gram positive bacteria in vitro and in vivo when given by intramuscular administration. Telomycin is poorly absorbed after oral administration. Despite its structural novelty, telomycin has received little attention. | [Uses]
Telomycin is an antibiotic that potently inhibits gram-postive bacteria. |
|
| Company Name: |
Lynnchem
|
| Telephone: |
86-(0)29-85992781 17792393971 |
| Website: |
http://www.lynnchem.com/ |
| Company Name: |
Energy Chemical
|
| Telephone: |
400-0056266 |
| Website: |
www.energy-chemical.com |
|