| Identification | Back Directory | [Name]
(5S)-1-[2-Chloro-4-(1-pyrrolidinyl)benzoyl]-2,3,4,5-tetrahydro-N-(1-methylethyl)-1H-1-benzazepine-5-acetamide | [CAS]
192514-57-1 | [Synonyms]
(-)-OPC-51803
(5S)-1-[2-Chloro-4-(1-pyrrolidinyl)benzoyl]-2,3,4,5-tetrahydro-N-(1-methylethyl)-1H-1-benzazepine-5-acetamide
(S)-2-(1-(2-chloro-4-(pyrrolidin-1-yl)benzoyl)-2,3,4,5-tetrahydro-1H-benzo[b]azepin-5-yl)-N-isopropylacetamide | [Molecular Formula]
C26H32ClN3O2 | [MOL File]
192514-57-1.mol | [Molecular Weight]
454.01 |
| Chemical Properties | Back Directory | [Melting point ]
182.5-184.5 °C | [Boiling point ]
681.6±55.0 °C(Predicted) | [density ]
1.188±0.06 g/cm3(Temp: 20 °C; Press: 760 Torr)(Predicted) | [pka]
15.92±0.46(Predicted) |
| Hazard Information | Back Directory | [Uses]
(S)-OPC-51803 is an agonist of the vasopressin V2 receptor, with activity in suppressing nocturia and urinary incontinence. (S)-OPC-51803 was evaluated in terms of biological activity and showed a stronger V2 receptor agonist effect compared to its (R)-isomer. The use of (S)-OPC-51803 may improve the patient's ability to control nocturnal polyuria[1]. | [References]
[1] Characterization of orally active nonpeptide vasopressin V(2) receptor agonist. Synthesis and biological evaluation of both the (5R)- and (5S)-enantioisomers of 2-[1-(2-Chloro-4-pyrrolidin-1-yl-benzoyl)-2,3,4,5-tetrahydro-1H-1-benzazepin- 5-yl]-N-isopropylacetamide |
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| Company Name: |
Biorbyt Ltd.
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| Tel: |
+44 (0)1223 859 353 |
| Website: |
http://www.biorbyt.com |
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