| Identification | Back Directory | [Name]
[(2R,3R,4R,5R)-5-(6-aminopurin-9-yl)-4-hydroxy-2-[[hydroxy-[hydroxy-[(3R)-3-hydroxy-3-[2-[2-(2-hydroxypropanoylsulfanyl)ethylcarbamoyl]ethylcarbamoyl]-2,2-dimethyl-propoxy]phosphoryl]oxy-phosphoryl]oxymethyl]oxolan-3-yl]oxyphosphonic acid | [CAS]
1926-57-4 | [Synonyms]
Lactyl-CoA
lactoyl-CoA
lactoyl-coenzyme A
Coenzyme A, S-(2-hydroxypropanoate)
[(2R,3R,4R,5R)-5-(6-aminopurin-9-yl)-4-hydroxy-2-[[hydroxy-[hydroxy-[(3R)-3-hydroxy-3-[2-[2-(2-hydroxypropanoylsulfanyl)ethylcarbamoyl]ethylcarbamoyl]-2,2-dimethyl-propoxy]phosphoryl]oxy-phosphoryl]oxymethyl]oxolan-3-yl]oxyphosphonic acid | [Molecular Formula]
C24H40N7O18P3S | [MOL File]
1926-57-4.mol | [Molecular Weight]
839.6 |
| Chemical Properties | Back Directory | [density ]
1.91±0.1 g/cm3(Predicted) | [form ]
Solid | [pka]
1.16±0.50(Predicted) | [color ]
White to off-white | [InChIKey]
ACMRCAATBMZKRY-IBNUZSNCSA-N | [SMILES]
SCCNC(=O)CCNC(=O)[C@H](OC(=O)[C@@H](O)C)C(COP(=O)(O)OP(=O)(O)OC[C@H]1O[C@@H](N2C3N=CN=C(N)C=3N=C2)[C@H](O)[C@@H]1OP(=O)(O)O)(C)C |
| Hazard Information | Back Directory | [Uses]
Lactyl-CoA is an acyl-CoA formally condensed from the sulfhydryl group of CoA and the carboxyl group of lactic acid, also known as lactyl-CoA. Lactyl-CoA is essential for the biosynthesis of biodegradable and biocompatible lactic acid-based copolymers[1][2]. | [Definition]
ChEBI: An acyl-CoA that results from the formal condensation of the thiol group of coenzyme A with the carboxy group of lactic acid. | [References]
[1] Liu R, et al. Nuclear GTPSCS functions as a lactyl-CoA synthetase to promote histone lactylation and gliomagenesis. Cell Metab. 2025 Feb 4;37(2):377-394.e9. DOI:10.1016/j.cmet.2024.11.005
[2] Xiaoxia Zhang, et al. Screening, expression, purification and characterization of CoA-transferases for lactoyl-CoA generation. J Ind Microbiol Biotechnol. 2019 Jul;46(7):899-909. DOI:10.1007/s10295-019-02174-6 |
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