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192705-80-9

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192705-80-9 Structure

192705-80-9 Structure
IdentificationBack Directory
[Name]

N-[6-(2,6-Dichlorophenyl)-2-[[4-(diethylamino)butyl]amino]pyrido[2,3-d]pyrimidin-7-yl]-N'-(1,1-dimethylethyl)urea
[CAS]

192705-80-9
[Synonyms]

PD 161570
PF-1480232
PD-161570;PF-1480232
1-(tert-Butyl)-3-(6-(2,6-dichlorophenyl)-2-((4-(diethylamino)butyl)amino)pyrido[2,3-d]pyrimidi
1-Tert-butyl-3-[6-(2,6-dichloro-phenyl)-2-(4-diethylaMino-butylaMino)pyrido[2,3-d]pyriMidin-7-yl]urea
N-[6-(2,6-Dichlorophenyl)-2-[[4-(diethylamino)butyl]amino]pyrido[2,3-d]pyrimidin-7-yl]-N'-(1,1-dimethylethyl)urea
[Molecular Formula]

C26H35Cl2N7O
[MDL Number]

MFCD16618403
[MOL File]

192705-80-9.mol
[Molecular Weight]

532.51
Chemical PropertiesBack Directory
[Melting point ]

215-230?C
[density ]

1.249±0.06 g/cm3(Predicted)
[storage temp. ]

Store at RT
[solubility ]

DMSO: >10mg/mL
[form ]

powder
[pka]

9.82±0.43(Predicted)
[color ]

white to off-white
[InChIKey]

MKVMEJKNLUWFSQ-UHFFFAOYSA-N
[SMILES]

CCN(CC)CCCCNc1ncc2cc(c(NC(=O)NC(C)(C)C)nc2n1)-c3c(Cl)cccc3Cl
Safety DataBack Directory
[Hazard Codes ]

T
[Risk Statements ]

25-36/37/38
[Safety Statements ]

26-45
[RIDADR ]

UN 2811 6.1 / PGIII
[WGK Germany ]

3
[Storage Class]

6.1C - Combustible acute toxic Cat.3
toxic compounds or compounds which causing chronic effects
[Hazard Classifications]

Acute Tox. 3 Oral
Eye Irrit. 2
Skin Irrit. 2
STOT SE 3
Hazard InformationBack Directory
[Chemical Properties]

Off-White Solid
[Uses]

A novel FGF-1 receptor tyrosine kinase inhibitor which has been shown to effectively suppress constitutive phosphorylation of the FGF-1 receptor in human ovarian carcinoma cells.
[Biological Activity]

PD-161570 is an inhibitor of human FGF-1 receptor tyrosine kinase.
[IC 50]

FGFR1: 39.9 nM (IC50); FGFR1: 42 nM (Ki); FGFR1 autophosphorylation: 622 nM (IC50); PDGFRβ: 262 nM (IC50); PDGFR: 310 nM (IC50); EGFR: 240 nM (IC50); c-Src: 44 nM (IC50); TGF-β Receptor
[storage]

Store at -20°C
Spectrum DetailBack Directory
[Spectrum Detail]

N-[6-(2,6-Dichlorophenyl)-2-[[4-(diethylamino)butyl]amino]pyrido[2,3-d]pyrimidin-7-yl]-N'-(1,1-dimethylethyl)urea(192705-80-9)1HNMR
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