| Identification | Back Directory | [Name]
LY310762 | [CAS]
192927-92-7 | [Synonyms]
CS-195
LY 310762 HCl
LY310762;LY-310762
LY310762 USP/EP/BP
LY-310,762 HYDROCHLORIDE
1-[2-[4-(4-fluorobenzoyl)piperidin-1-yl]ethyl]-3,3-dimethylindol-2-one
1-[2-[4-(4-fluorobenzoyl)piperidin-1-yl]ethyl]-3,3-dimethylindol-2-one,hydrochloride
1-(2-(4-(4-fluorobenzoyl)piperidin-1-yl)ethyl)-3,3-diMethylindolin-2-one Hydrochloride
1-[2-[4-(4-Fluorobenzoyl)-1-piperidinyl]ethyl]-1,3-dihydro-3,3-dimethyl-2H-indol-2-onehydrochloride
3,3-Dimethyl-1-{2-[4-(4-fluorobenzoyl)-1-piperidinyl]-1-ethyl}-1,3-dihydro-2H-indol-2-one hydrochloride
2H-Indol-2-one, 1-[2-[4-(4-fluorobenzoyl)-1-piperidinyl]ethyl]-1,3-dihydro-3,3-diMethyl-, Monohydrochloride | [Molecular Formula]
C24H27O2N2FHCl | [MDL Number]
MFCD03457395 | [MOL File]
192927-92-7.mol |
| Hazard Information | Back Directory | [Uses]
LY-310762 Hydrochloride is a selective and potent SR-1D and 5-hydroxytryptamine (5-HT1D) receptor-preferring antagonist. | [Definition]
ChEBI:LY-310762 hydrochloride is a hydrochloride resulting from the formal reation of equimolar amount of LY-310762 with hydrogen chloride. A potent and selective antagonist for the 5-hydroxytryptamine 1D (5-HT1D) receptor. It has a role as a receptor modulator and a serotonergic antagonist. It contains a LY-310762(1+). | [Biological Activity]
5-HT 1D -preferring receptor antagonist (EC 50 = 31 nM). Displays no activity on 5-HT transport. | [in vivo]
LY310762 (10 mg/kg; i.p.; single) significantly increases the extracellular 5-HT concentration produced by Fluoxetine (selective serotonin re-uptake inhibitor) in vivo[1].
LY310762 (1 mg/kg; i.v.; single) abolishes 5-HT vasodilator effects in phenylephrine-infusion rats model[2]. | Animal Model: | Dunkin Hartley guinea pigs (female; 350-400 g, Harlan)[1]. | | Dosage: | 10 mg/kg | | Administration: | Intraperitoneal injection; single | | Result: | Produced a further significant enhancement in the 5-HT response to fluoxetine. |
| Animal Model: | Male Wistar rats (270-330 g; phenylephrine-infusion rats model)[2]. | | Dosage: | 1 mg/kg | | Administration: | Intravenous injection; single | | Result: | Completely abolished 5-HT vasodilator effects. |
| [IC 50]
5-HT1D Receptor: 249 nM (Ki) | [storage]
Store at -20°C |
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