| Chemical Properties | Back Directory | [density ]
1.42±0.1 g/cm3(Predicted) | [solubility ]
DMF: 3 mg/ml; DMSO: 1 mg/ml; Ethanol: insol; PBS (pH 7.2): insol | [form ]
A crystalline solid | [pka]
13.89±0.46(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Uses]
Zelatriazin (TAK-041; NBI-1065846) is a potent and selective GPR139 agonist with an EC50 of 22 nM. Zelatriazin has the potential for the research of negative symptoms associated with schizophrenia[1]. | [in vivo]
Zelatriazin (0.03-3 mg/kg; P.o.) improves social behavior in BALB/c mice[1]. | Animal Model: | BALB/c mice[1] | | Dosage: | 0.03, 0.3, and 3 mg/kg | | Administration: | P.o. | | Result: | Dose-dependently improved the social behavior of BALB/c mice.
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| [References]
[1] Reichard HA, et al. Discovery of TAK-041: a Potent and Selective GPR139 Agonist Explored for the Treatment of Negative Symptoms Associated with Schizophrenia [published online ahead of print, 2021 Jul 14]. J Med Chem. 2021;10.1021/acs.jmedchem.1c00820. DOI:10.1021/acs.jmedchem.1c00820 |
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