| Identification | Back Directory | [Name]
Tabimorelin | [CAS]
193079-69-5 | [Synonyms]
NNC260703
NNC-260703
NNC26-0703
NNC-26-0703
Tabimorelin
Unii-L51cbe03kf
Tabimorelin [inn]
N-[5-Amino-5-Methyl-2(E)-Hexenoyl]-N-Methyl-3-(2- Naphthyl)-D-Alanyl-N-Methyl-D-Phenylalanine Methylamide
N-[(2E)-5-Amino-5-methyl-1-oxo-2-hexenyl]-N-methyl-3-(2-naphthalenyl)-D-alanyl-N,Nα-dimethyl-D-phenylalaninamidehemifumarate | [Molecular Formula]
2C32H40N4O3.C4H4O4 | [MDL Number]
MFCD19105422 | [MOL File]
193079-69-5.mol | [Molecular Weight]
1173.46 |
| Chemical Properties | Back Directory | [Melting point ]
>70°C(dec.) | [Boiling point ]
794.4±60.0 °C(Predicted) | [density ]
1.146±0.06 g/cm3(Predicted) | [storage temp. ]
Desiccate at RT | [solubility ]
Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly) | [form ]
Solid | [pka]
15.14±0.46(Predicted) | [color ]
White to Off-White | [Stability:]
Light Sensitive |
| Hazard Information | Back Directory | [Uses]
NN703 (Tabimorelin) is an orally active growth hormone (GH) secretagogue intended for use as an alternative to daily injections of GH. In vitro studies in human liver microsomes have indicated that NN703 is a mechanism-based inhibitor of CYP3A4. | [Biological Activity]
Potent, orally active ghrelin receptor (GHS-R1a) agonist (K i = 50 nM at human recombinant GHS-R1a). Stimulates GH release from rat pituitary cells with an EC 50 value of 2.7 nM. Induces hyperphagia and adiposity in lean rats, but not in leptin signaling-deficient ZDF rats. | [IC 50]
CYP3A4 |
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