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193273-66-4

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193273-66-4 Structure

193273-66-4 Structure
IdentificationBack Directory
[Name]

Capromorelin
[CAS]

193273-66-4
[Synonyms]

391
CP-424
CS-1525
CP 424391
Capromorelin
CP 424391; CP-424;391
CP-424391, Capromorelin
Caprimorelin (Capromorelin)
(3aR)-3a-benzyl-2-Methyl-5-(2-Methylalanyl-O-benzyl-D-seryl)-3-oxo-3,3a,4,5,6,7-hexahydro-2H-pyrazolo[4,3-c]pyridine
N-[(2R)-1-[(3~{a}R)-3~{a}-benzyl-2-methyl-3-oxo-6,7-dihydro-4~{H}-pyrazolo[4,3-c]pyridin-5-yl]-1-oxo-3-phenylmethoxypropan-2-yl]-2-amino-2-methylpropanamide
N-[(2R)-1-[(3aR)-2-Methyl-3-oxo-3a-(phenylmethyl)-6,7-dihydro-4H-pyrazolo[4,3-c]pyridin-5-yl]-1-oxo-3-(phenylmethoxy)propan-2-yl]-2-amino-2-methylpropanamide
Propanamide, 2-amino-N-[(1R)-2-[(3aR)-2,3,3a,4,6,7-hexahydro-2-methyl-3-oxo-3a-(phenylmethyl)-5H-pyrazolo[4,3-c]pyridin-5-yl]-2-oxo-1-[(phenylmethoxy)methyl]ethyl]-2-methyl-
[Molecular Formula]

C28H35N5O4
[MOL File]

193273-66-4.mol
[Molecular Weight]

505.61
Chemical PropertiesBack Directory
[density ]

1.25
[pka]

15?+-.0.46(Predicted)
Hazard InformationBack Directory
[Uses]

Treatment and prevention of frailty; treatment of congestive heart failure; treatment of catabolic illness (growth hormone secretagogue).
[in vivo]

Capromorelin increases plasma GH levels in an anesthesized rat model, with an ED50 value less than 0.05 mg/kg iv[1].
Capromorelin shows enhanced intestinal absorption in rodent models and exhibited superior pharmacokinetic properties, including high bioavailabilities in two animal species [F(rat)=65%, F(dog)=44%][1].

[IC 50]

GHSR1a: 7 nM (Ki)
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