| Identification | Back Directory | [Name]
3-PHENYL-4-PICOLINE | [CAS]
19352-29-5 | [Synonyms]
3-PHENYL-4-PICOLINE
4-METHYL-3-PHENYLPYRIDINE
Pyridine, 4-methyl-3-phenyl- | [Molecular Formula]
C12H11N | [MDL Number]
MFCD04114238 | [MOL File]
19352-29-5.mol | [Molecular Weight]
169.22 |
| Hazard Information | Back Directory | [Synthesis]
Pd Catalyst 1 (12.6 mg, 0.045 mmol, calculated based on the molar concentration of Pd) and 3-chloro-4-methylpyridine (0.2 mmol) were added to a Schlenk tube equipped with a magnetic stir bar. Anhydrous toluene (2.0 mL) and phenylmagnesium bromide (0.3 mmol, 1.5 equiv) were added sequentially under nitrogen protection. The reaction mixture was heated to 140 °C and the reaction was stirred at this temperature until complete consumption of 3-chloro-4-methylpyridine was confirmed by thin layer chromatography (TLC) monitoring. Upon completion of the reaction, the reaction mixture was purified by silica gel column chromatography to afford the target product 3-phenyl-4-methylpyridine. | [References]
[1] Tetrahedron, 2016, vol. 72, # 1, p. 69 - 75 |
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