| Identification | Back Directory | [Name]
N,N-DiMethylpropionaMidediMethylacetale | [CAS]
19429-86-8 | [Synonyms]
N,N-DiMethylpropionaMidediMethylacetale
N,N-Dimethylpropionamide Dimethyl Acetal
1,1-dimethoxy-N,N-dimethylpropan-1-amine
1,1-Dimethoxy-N,N-dimethyl-1-propanamine
1-Propanamine, 1,1-dimethoxy-N,N-dimethyl- | [Molecular Formula]
C7H17NO2 | [MOL File]
19429-86-8.mol | [Molecular Weight]
147.22 |
| Chemical Properties | Back Directory | [Boiling point ]
30 °C(Press: 12 Torr) | [density ]
0.897±0.06 g/cm3(Predicted) | [solubility ]
sol benzene and xylene. | [pka]
5.08±0.50(Predicted) |
| Hazard Information | Back Directory | [Uses]
N,N-Dimethylpropionamide Dimethyl Acetal is used as reagents for stereoselective Eschenmoser-Claisen rearrangements[1] to give γ,δ-unsaturated amides, or, via
subsequent protodesilation, to give β,γ-unsaturated amides.
| [storage]
N,N-Dimethylpropionamide Dimethyl Acetal is potentially toxic and flammable. They should be handled in a fume hood. | [References]
1. For recent reviews on Claisen rearrangements, see: (a) Wipf, P. COS 1991, 5, Chapter 7.2. (b) Kallmarten, J.;
Wittman, M. D. Stud. Nat. Prod. Chem. 1989, 3, 233. (c) Blechert, S. S 1989, 71. (d) Ziegler, F. E. CRV 1988, 88, 1423.
(e) Moody, C. J. Adv. Heterocycl. Chem. 1987, 42, 203.
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