| Identification | Back Directory | [Name]
N-(Benzenesulfonyl)-L-prolyl-L-O-(1-pyrrolidinylcarbonyl)tyrosine sodium salt | [CAS]
1947348-42-6 | [Synonyms]
BOP sodium
BOP sodium salt
BOP >97% (HPLC)
N-(Benzenesulfonyl)-L-prolyl-L-O-(1-pyrrolidinylcarbonyl)tyrosine sodium salt | [Molecular Formula]
C25H28N3NaO7S | [MDL Number]
MFCD30729653 | [MOL File]
1947348-42-6.mol | [Molecular Weight]
537.56 |
| Chemical Properties | Back Directory | [storage temp. ]
Store at -20°C | [solubility ]
Soluble in DMSO | [form ]
Solid | [color ]
White to off-white | [Water Solubility ]
H2O: 2mg/mL, clear (warmed) |
| Hazard Information | Back Directory | [Uses]
BOP sodium is a potent and selective dual α9β1/α4β1 integrin inhibitor with Kd values in the picomolar range. BOP sodium shows the rapid and preferential mobilization of hematopoietic stem cell (HSC) and progenitors. BOP sodium has little inhibitory activity on α4β7, α1β1, α2β1, and α5β1, αIIBβ3 integrins[1][2]. | [Biological Activity]
BOP (N-(Benzenesulfonyl)-L-prolyl-L-O-(1-pyrrolidinylcarbonyl)tyrosine sodium salt) is a potent and selective dual inhibitor of integrins alpha-4 beta-1 (α4β1) and alpha-9 beta-1 (α9β1) with Kd values in the picomolar range. BOP has been shown to preferentially mobilize hematopoietic stem cells (HSCs) and progenitors and to act synergistically with AMD3100. | [IC 50]
α4β1; α9β1 | [storage]
Store at -20°C | [References]
[1] R Blake Pepinsky, et al. Comparative assessment of the ligand and metal ion binding properties of integrins alpha9beta1 and alpha4beta1. Biochemistry. 2002 Jun 4;41(22):7125-41. DOI:10.1021/bi020024d
[2] Benjamin Cao, et al. Therapeutic targeting and rapid mobilization of endosteal HSC using a small molecule integrin antagonist. Nat Commun. 2016 Mar 15;7:11007. DOI:10.1038/ncomms11007 |
|
| Company Name: |
BOC Sciences
|
| Tel: |
1-631-485-4226; 16314854226 |
| Website: |
https://www.bocsci.com |
| Company Name: |
Energy Chemical
|
| Tel: |
021-58432009 400-005-6266 |
| Website: |
http://www.energy-chemical.com |
| Company Name: |
R&D Systems, Inc
|
| Tel: |
18003437475 18003437475 |
| Website: |
www.rndsystems.com |
| Company Name: |
Merck KGaA
|
| Tel: |
21-20338288 |
| Website: |
www.sigmaaldrich.cn |
| Company Name: |
MedChemExpress
|
| Tel: |
021-58955995 |
| Website: |
www.medchemexpress.com |
|