1948229-21-7

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1948229-21-7 Structure

Identification	Back Directory
[Name] Eliapixant
[CAS] 1948229-21-7
[Synonyms] Eliapixant BAY 1817080 Benzamide, 3-(5-methyl-2-thiazolyl)-5-[[(3R)-tetrahydro-3-furanyl]oxy]-N-[(1R)-1-[2-(trifluoromethyl)-5-pyrimidinyl]ethyl]-
[Molecular Formula] C22H21F3N4O3S
[MDL Number] MFCD34470055
[MOL File] 1948229-21-7.mol
[Molecular Weight] 478.49

Hazard Information	Back Directory
[Uses] Eliapixant (BAY 1817080) is a potent and selective antagonist of P2X3 receptor, with an IC50 of 8 nM. Eliapixant can be used for the research of refractory chronic cough[1][2].
[in vivo] Eliapixant can be used for the research of coughs and diabetes complications^[1].
[IC 50] P2X3 Receptor
[References] [1] Spinaci A, et, al. P2X3 Receptor Ligands: Structural Features and Potential Therapeutic Applications. Front Pharmacol. 2021 Apr 13;12:653561. DOI:10.3389/fphar.2021.653561 [2] Morice A, et, al. Eliapixant (BAY 1817080), a P2X3 receptor antagonist, in refractory chronic cough: a randomised, placebo-controlled, crossover phase 2a study. Eur Respir J. 2021 May 13;2004240. DOI:10.1183/13993003.04240-2020

Spectrum Detail	Back Directory
[Spectrum Detail] Eliapixant(1948229-21-7)¹HNMR

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