| Identification | Back Directory | [Name]
Tos-PEG5-CH2COOtBu | [CAS]
1949793-62-7 | [Synonyms]
Tos-PEG5-CH2COOtBu Tos-PEG6-CH2CO2tBu (2-[2-(2-(2-[2-(Toluene-4-sulfonyloxy)-ethoxy]-ethoxy)-ethoxy)-ethoxy]-ethoxy)-acetic acid tert-butyl ester | [Molecular Formula]
C23H38O10S | [MDL Number]
MFCD30828689 | [MOL File]
1949793-62-7.mol | [Molecular Weight]
506.61 |
| Chemical Properties | Back Directory | [Boiling point ]
581.2±50.0 °C(Predicted) | [density ]
1.159±0.06 g/cm3(Predicted) | [storage temp. ]
Store at 0-8 °C | [Appearance]
yellow liquid |
| Hazard Information | Back Directory | [Description]
Tos-PEG6-CH2CO2tBu is a PEG linker containing a t-butyl ester and a tosyl group. The hydrophilic PEG spacer increases solubility in aqueous media. The t-butyl protected carboxyl group can be deprotected under acidic conditions. The tosyl group is a very good leaving group for nucleophilic substitution reactions. | [Uses]
Tos-PEG5-CH2COOtBu is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. | [IC 50]
PEGs; Alkyl/ether | [References]
[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005 |
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