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1949801-52-8

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1949801-52-8 Structure

1949801-52-8 Structure
IdentificationBack Directory
[Name]

LXRβ agonist-2
[CAS]

1949801-52-8
[Synonyms]

LXRβ agonist-2
LXRΒ AGONIST-2
[Molecular Formula]

C32H31F6N3O7
[MDL Number]

MFCD32174230
[MOL File]

1949801-52-8.mol
[Molecular Weight]

683.59
Chemical PropertiesBack Directory
[density ]

1.373±0.06 g/cm3(Predicted)
[storage temp. ]

Store at -20°C
[solubility ]

Soluble in DMSO
[pka]

6.21±0.70(Predicted)
Hazard InformationBack Directory
[Uses]

LXRβ agonist-2 is a highly potent and β-selective liver X receptor (LXRβ) agonist with EC50 of 7 nM, displays 28.5-fold selectivity over LXRα (EC50=200 nM) and used in the treatment of atherosclerosis[1].
[References]

[1] Koura M,et al. Discovery of a 2-hydroxyacetophenone derivative as an outstanding linker to enhance potency and β-selectivity of liver X receptor agonist. Bioorg Med Chem. 2016 Aug 15;24(16):3436-46. DOI:10.1016/j.bmc.2016.05.048
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