| Identification | Back Directory | [Name]
3-METHYL-N-[(1R)-1-METHYL-3-(4-METHYL-1-PIPERIDINYL)PROPYL]-N-METHYLBENZENESULFONAMIDE HYDROCHLORIDE | [CAS]
195199-95-2 | [Synonyms]
SB 258719
SB-258719 >=98% (HPLC)
SB 258719 HYDROCHLORIDE
Benzenesulfonamide, N,3-dimethyl-N-[(1R)-1-methyl-3-(4-methyl-1-piperidinyl)propyl]-
3-METHYL-N-[(1R)-1-METHYL-3-(4-METHYL-1-PIPERIDINYL)PROPYL]-N-METHYLBENZENESULFONAMIDE HYDROCHLORIDE | [Molecular Formula]
C18H30N2O2S | [MDL Number]
MFCD09971125 | [MOL File]
195199-95-2.mol | [Molecular Weight]
338.51 |
| Chemical Properties | Back Directory | [Boiling point ]
463.6±55.0 °C(Predicted) | [density ]
1.075±0.06 g/cm3(Predicted) | [storage temp. ]
Desiccate at RT | [solubility ]
DMSO: 250 mg/mL (738.53 mM) | [form ]
Liquid | [pka]
9.36±0.10(Predicted) | [color ]
Light yellow to yellow | [InChI]
1S/C18H30N2O2S/c1-15-8-11-20(12-9-15)13-10-17(3)19(4)23(21,22)18-7-5-6-16(2)14-18/h5-7,14-15,17H,8-13H2,1-4H3 | [InChIKey]
AGVNHDNTFYHZNL-UHFFFAOYSA-N | [SMILES]
CC1=CC=CC(S(N(C)[C@H](C)CCN2CCC(C)CC2)(=O)=O)=C1 |
| Safety Data | Back Directory | [WGK Germany ]
WGK 3 | [Storage Class]
11 - Combustible Solids | [Hazard Classifications]
Eye Irrit. 2
Skin Irrit. 2
STOT SE 3 |
| Hazard Information | Back Directory | [Uses]
SB 258719 Hydrochloride is a useful intermediate. | [Biological Activity]
Selective 5-HT 7 receptor antagonist that displays > 100-fold selectivity over a range of other receptors. Reverses the hypothermic effect of 5-CT in mice following i.p. administration. | [in vivo]
SB 258719 (5-20 mg/kg; i.p.) significantly attenuates the 5-CT-induced hypothermia[2]. | Animal Model: | Male Swiss Webster mice (20-25 g)[2]. | | Dosage: | 5-20 mg/kg | | Administration: | I.p. | | Result: | Significantly attenuated the 5-CT-induced hypothermia.
|
| [IC 50]
5-HT7 Receptor: 7.5 (pKi) |
|
| Company Name: |
Energy Chemical
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| Tel: |
021-58432009 400-005-6266 |
| Website: |
http://www.energy-chemical.com |
| Company Name: |
cjbscvictory
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| Tel: |
13348960310 |
| Website: |
https://www.weikeqi-biotech.com/ |
| Company Name: |
Merck KGaA
|
| Tel: |
21-20338288 |
| Website: |
www.sigmaaldrich.cn |
| Company Name: |
MedChemExpress
|
| Tel: |
021-58955995 |
| Website: |
www.medchemexpress.com |
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