| Identification | Back Directory | [Name]
4,7,10,13,16,23-Hexaoxa-20,27,31-triazahexatriacontanoic acid, 36-[[2-(acetylamino)-2-deoxy-β-D-galactopyranosyl]oxy]-21,21-bis[[3-[[3-[[5-[[2-(acetylamino)-2-deoxy-β-D-galactopyranosyl]oxy]-1-oxopentyl]amino]propyl]amino]-3-oxopropoxy]methyl]-19,26,32-trioxo-, 2,5-dioxo-1-pyrrolidinyl ester | [CAS]
1953146-83-2 | [Synonyms]
Tri-GalNAc-NHS ester
4,7,10,13,16,23-Hexaoxa-20,27,31-triazahexatriacontanoic acid, 36-[[2-(acetylamino)-2-deoxy-β-D-galactopyranosyl]oxy]-21,21-bis[[3-[[3-[[5-[[2-(acetylamino)-2-deoxy-β-D-galactopyranosyl]oxy]-1-oxopentyl]amino]propyl]amino]-3-oxopropoxy]methyl]-19,26,32-trioxo-, 2,5-dioxo-1-pyrrolidinyl ester | [Molecular Formula]
C79H137N11O37 | [MOL File]
1953146-83-2.mol | [Molecular Weight]
1832.98 |
| Hazard Information | Back Directory | [Uses]
Tri-GalNAc-NHS ester is a LYsosome TArgeting Chimera (LYTAC) and a ligand of asialoglycoprotein receptor (ASGPR). ASGPR is a lysosomal targeting receptor specifically expressed on liver cells, for the degradation of extracellular proteins including membrane proteins. Tri-GalNAc-NHS ester can be used as a protein degrader and it can be used for the research of LYTAC[1]. | [References]
[1] Zhou Y, et al. Development of Triantennary N-Acetylgalactosamine Conjugates as Degraders for Extracellular Proteins. ACS Cent Sci. 2021 Mar 24;7(3):499-506. DOI:10.1021/acscentsci.1c00146 |
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DC Chemicals
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