| Identification | Back Directory | [Name]
Cyclopenin | [CAS]
19553-26-5 | [Synonyms]
)-Isocyclopenin
)-Isocyclopenine
rel-Isocyclopenine
Spiro[3H-1,4-benzodiazepine-3,2'-oxirane]-2,5(1H,4H)-dione, 4-methyl-3'-phenyl-, (2'R,3'R)-rel- | [Molecular Formula]
C17H14N2O3 | [MDL Number]
MFCD14635381 | [MOL File]
19553-26-5.mol | [Molecular Weight]
294.3 |
| Chemical Properties | Back Directory | [Boiling point ]
572.5±50.0 °C(Predicted) | [density ]
1.40±0.1 g/cm3(Predicted) | [form ]
powder | [pka]
12.92±0.40(Predicted) | [color ]
White to slightly pink |
| Hazard Information | Back Directory | [Uses]
(±)-Isocyclopenine is the racemic form of metabolites of natural product cyclopeptine (C991620) isolated from Penicillium cyclopium. Intermediate in the biosynthesis of the viridicatins. | [Uses]
Cyclopenin is one of an unusual family of benzodiazepine metabolites produced by a number of Penicillium species. Often mistakenly referred to as a mycotoxin, cyclopenin shows little toxicity against mammalian cells, bacteria or fungi in vitro. Cyclopenin is an intermediate in the biosynthesis of 3-O-methyl viridicatin, a strong inhibitor of TNFα-induced replication HIV. Lack of availability has hitherto restricted a more intensive investigation of this interesting metabolite. | [storage]
+4°C |
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