| Identification | Back Directory | [Name]
2-Thiazolamine, 4-methyl-N-1-naphthalenyl- | [CAS]
1957-01-3 | [Synonyms]
CCR4 antagonist 3-1
2-Thiazolamine, 4-methyl-N-1-naphthalenyl- | [Molecular Formula]
C14H12N2S | [MOL File]
1957-01-3.mol | [Molecular Weight]
240.32 |
| Chemical Properties | Back Directory | [Melting point ]
148-150 °C | [Boiling point ]
416.9±38.0 °C(Predicted) | [density ]
1.274±0.06 g/cm3(Predicted) | [form ]
Solid | [pka]
4.44±0.10(Predicted) | [color ]
Off-white to light yellow |
| Hazard Information | Back Directory | [Uses]
CCR4 antagonist 3 is a potent chemokine receptor 4 (CCR4) antagonist with an IC50 value of 1.7 μM for [125I]TARC (thymus and activation regulated chemokine). CCR4 antagonist 3 inhibits binding of radiolabeled TARC and macrophage-derived chemokine (MDC) to CCR4 receptors on the surface of CEM cells. CCR4 antagonist 3 also inhibits the in vitro migration of CEM cells mediated by TARC (IC50 = 6.4 μM)[1]. | [in vivo]
CCR4 antagonist 3 (compound 1) (0.5 mg/kg for IV; 2 mg/kg for PO; single dosage) exhibits a high clearance, short half-life and low oral bioavailability[1]. | Animal Model: | Rats[1] | | Dosage: | 0.5 mg/kg for IV; 2 mg/kg for PO | | Administration: | IV and PO; single dosage | | Result: | Exhibited a high clearance of 4.2 L/h/kg and a short half-life of 0.4 h, and the oral bioavailability of 2%. |
| [IC 50]
[125I]-TARC-CCR4: 1.7 μM (IC50) | [References]
[1] Wang X, et al. Optimization of 2-aminothiazole derivatives as CCR4 antagonists. Bioorg Med Chem Lett. 2006 May 15;16(10):2800-3. DOI:10.1016/j.bmcl.2006.01.126 |
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