| Chemical Properties | Back Directory | [Boiling point ]
526.8±60.0 °C(Predicted) | [density ]
1.278±0.06 g/cm3(Predicted) | [form ]
Solid | [pka]
8.71±0.60(Predicted) | [color ]
Light green to green |
| Hazard Information | Back Directory | [Uses]
SHP836 is a SHP2 allosteric inhibitor, with an IC50 of 12 μM for the full length SHP2[1]. | [References]
[1] Liu WS, et al. Structure based design of selective SHP2 inhibitors by De novo design, synthesis and biological evaluation. J Comput Aided Mol Des. 2019 Aug;33(8):759-774. DOI:10.1007/s10822-019-00213-z
[2] Garcia Fortanet J, et al. Allosteric Inhibition of SHP2: Identification of a Potent, Selective, and Orally Efficacious Phosphatase Inhibitor. J Med Chem. 2016 Sep 8;59(17):7773-82. DOI:10.1021/acs.jmedchem.6b00680 |
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