| Identification | Back Directory | [Name]
EXENDIN (5-39) | [CAS]
196109-27-0 | [Synonyms]
EXENDIN (5-39)
Exendin 4 (5-39)amide
THR-PHE-THR-SER-ASP-LEU-SER-LYS-GLN-MET-GLU-GLU-GLU-ALA-VAL-ARG-LEU-PHE-ILE-GLU-TRP-LEU-LYS-ASN-GLY-GLY-PRO-SER-SER-GLY-ALA-PRO-PRO-PRO-SER-NH2 | [MDL Number]
MFCD01634833 |
| Hazard Information | Back Directory | [Uses]
Exendin (5-39) is a potent glucagon-like peptide 1 (GLP-1) receptor antagonist. Exendin (5-39) improves memory impairment in β-amyloid protein-treated rats[1]. | [in vivo]
Exendin (5-39) (intracerebroventricular injection; 0.3 μg; once daily; 1-week) increases GLT-1 protein levels in the hippocampus of male Wistar rats. Additionally, hippocampal slices are prepared from Ex-treated or vehicle rats,Exendin (5-39) decreases fEPSP decay time and increases the input-output relation and decreased the paired-pulse ratio in the dentate gyrus (DG). Furthermore, Ex inhibits long-term depression but not long-term potentiation in the DG[1]. | Animal Model: | Wistar rats (3 weeks old and 18 days pregnant)[1] | | Dosage: | 0.3 μg | | Administration: | Intracerebroventricular injection; 0.3 μg; once daily; 1-week | | Result: | Inhibited GLT-1 protein levels and inhibited long-term depression in rats.
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| [References]
[1] Kazuma Kobayashi, et al. Exendin (5-39), an antagonist of GLP-1 receptor, modulates synaptic transmission via glutamate uptake in the dentate gyrus. Brain Res. 2013 Apr 10;1505:1-10. DOI:10.1016/j.brainres.2013.01.012 |
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Boao Pike
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010-57798038 15652371397 |
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www.biopike.cn |
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