| Identification | Back Directory | [Name]
Xanthine amine congener dihydrochloride | [CAS]
1962928-23-9 | [Synonyms]
Xanthine amine congener dihydrochloride | [MDL Number]
MFCD30182228 |
| Hazard Information | Back Directory | [Uses]
Xanthine amine congener dihydrochloride (XAC dihydrochloride) is a potent Adenosine A1 receptor and A2?receptor antagonist with IC50 values of 1.8 and 114 nM, respectively. Xanthine amine congener acts as a convulsant agent in mice model[1]. | [Biological Activity]
XAC is an adenosine receptor antagonist (IC50 values are 1.8 and 114 nM at A1 and A2 receptors respectively). Attenuates adenosine-induced vasodilation and exhibits proconvulsant activity in vivo. | [in vivo]
Xanthine amine congener dihydrochloride is more potent as a convulsant than either caffeine or theophyllin in infusion studies at the dosage 39.8 mg/kg. XAC has no effects by administering the drug via an i.p. injection, the seizure threshold >1000 mg/kg[1]. | Animal Model: | Mice[1] | | Dosage: | 39.8 mg/kg | | Administration: | Infusion injection; single dose | | Result: | Acted as a convulsant agent than either caffeine or theophyllin. |
| [storage]
Desiccate at RT | [References]
[1] P F Morgan, et al.Potent Convulsant Actions of the Adenosine Receptor Antagonist, Xanthine Amine Congener (XAC). Life Sci. 1989;45(8):719-28 DOI:10.1016/0024-3205(89)90091-x |
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