| Identification | Back Directory | [Name]
Prosaptide TX14(A) | [CAS]
196391-82-9 | [Synonyms]
Prosaptide TX14(A)
THR-D-ALA-LEU-ILE-ASP-ASN-ASN-ALA-THR-GLU-GLU-ILE-LEU-TYR
L-Tyrosine, L-threonyl-D-alanyl-L-leucyl-L-isoleucyl-L-α-aspartyl-L-asparaginyl-L-asparaginyl-L-alanyl-L-threonyl-L-α-glutamyl-L-α-glutamyl-L-isoleucyl-L-leucyl- | [Molecular Formula]
C69H110N16O26 | [MDL Number]
MFCD06796054 | [MOL File]
196391-82-9.mol | [Molecular Weight]
1579.73 |
| Chemical Properties | Back Directory | [Boiling point ]
1954.9±65.0 °C(Predicted) | [density ]
1.326±0.06 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [form ]
Powder | [pka]
3.08±0.10(Predicted) | [color ]
White to off-white | [Water Solubility ]
Soluble to 2 mg/ml in water | [Sequence]
Thr-Ala-Leu-Ile-Asp-Asn-Asn-Ala-Thr-Glu-Glu-Ile-Leu-Tyr |
| Hazard Information | Back Directory | [Uses]
Prosaptide Tx 14(A) is a prosaposin-derived peptide with neuroprotective properties. It is able to cross the blood-brain barrier and a potential therapeutic agent for treating neurodegenerative diseases. | [Biological Activity]
Prosaptide Tx 14(A) is a potent agonist of G protein-coupled receptors GPR37 (also known as Parkin-associated endothelin receptor-like receptor Pael-R) and GPR37L1. Prosaptide Tx 14(A) is the active fragment of prosaposina secreted neuroprotective and glioprotective factor. Prosaptide Tx 14(A) has EC50 values of 5 nM for GPR37L1 and 7 nM for GPR37and has also been shown to have some GSK3 inhibitory properties. Prosaptide has been shown to improve nerve regeneration in diabetic ratsto reduce neuropathic painand to protect dopaminergic neurons in animal models of Parkinson disease. | [storage]
Store at -20°C |
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| Company Name: |
Energy Chemical
|
| Telephone: |
021-58432009 400-005-6266 |
| Website: |
http://www.energy-chemical.com |
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