| Identification | Back Directory | [Name]
5-BROMO-2-METHYL-1H-BENZIMIDAZOLE | [CAS]
1964-77-8 | [Synonyms]
5-bromo-2-methybenzimidazole
2-Methy-5-bromobenzimidazole
5-BROMO-2-METHYLBENZIMIDAZOLE
5-Bromo-2-methylbenzoimidazole
5-BROMO-2-METHYL-1H-BENZIMIDAZOLE
5-Bromo-2-methyl-1H-benzoimidazole
1H-BenziMidazole, 6-broMo-2-Methyl-
5-broMo-2-Methyl-1H-1,3-benzodiazole
5-BROMO-2-METHYL-1H-BENZ(D)IMIDAZOLE
5-BROMO-2-METHYL-1H-BENZO[D]IMIDAZOLE | [Molecular Formula]
C8H7BrN2 | [MDL Number]
MFCD00457521 | [MOL File]
1964-77-8.mol | [Molecular Weight]
211.06 |
| Chemical Properties | Back Directory | [Melting point ]
214-215 °C | [Boiling point ]
397.3±15.0 °C(Predicted) | [density ]
1.654±0.06 g/cm3(Predicted) | [storage temp. ]
Sealed in dry,Room Temperature | [form ]
solid | [pka]
10.50±0.10(Predicted) | [Appearance]
Light yellow to yellow Solid | [InChI]
InChI=1S/C8H7BrN2/c1-5-10-7-3-2-6(9)4-8(7)11-5/h2-4H,1H3,(H,10,11) | [InChIKey]
FHDFUQGJYYGLHJ-UHFFFAOYSA-N | [SMILES]
C1(C)NC2=CC(Br)=CC=C2N=1 |
| Questions And Answer | Back Directory | [Uses]
5-Bromo-2-methyl-1H-benzo[D]imidazole is a benzo[D]imidazole derivative. Benzimidazole compounds possess biological activities such as anti-HIV-1 activity, anti-tumor activity, anti-cell proliferation activity, anti-parasitic activity, anti-inflammatory activity, antioxidant activity, and anti-epileptic activity. In addition, these compounds are also used as metal ligands. Therefore, the synthesis of these compounds has attracted considerable attention from chemists. |
| Hazard Information | Back Directory | [Synthesis]
GENERAL METHOD: A mixture of 4-bromophthalimide (1.0 mmol), triethyl orthoacetate (1.2 mmol) and ZrCl4 (0.1 mmol) in 10 mL of methanol was stirred at room temperature for 3 hours. Upon completion of the reaction, the progress was monitored by TLC and the solvent was removed by concentration under reduced pressure. The crude product was purified by silica gel column chromatography with an eluent ratio of petroleum ether/ethyl acetate (4:1 to 1:1, v/v) to afford the target compound 5-bromo-2-methyl-1H-benzo[D]imidazole. | [References]
[1] European Journal of Medicinal Chemistry, 2015, vol. 90, p. 241 - 250 |
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| Company Name: |
Energy Chemical
|
| Telephone: |
400-0056266 |
| Website: |
www.energy-chemical.com |
| Company Name: |
Jia Xing Isenchem Co.,Ltd
|
| Telephone: |
0573-85285100 18627885956 |
| Website: |
https://www.chemicalbook.com/ShowSupplierProductsList14265/0_EN.htm |
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