| Identification | Back Directory | [Name]
IGF-1R Inhibitor II, N-(5-Chloro-2-methoxyphenyl)-Nμ-(2-methylquinolin-4-yl)urea | [CAS]
196868-63-0 | [Synonyms]
PQ401
CS-764
PQ401, >=98%
PQ-401; PQ 401
PQ401 hydrochloride
IGF-1R Inhibitor II
IGF-1R Inhibitor II, PQ401
N-(5-chloro-2-methoxyphenyl)-N'-(2-methyl-4-quinolinyl)-
IGF-1R Inhibitor II, PQ401 - CAS 196868-63-0 - Calbiochem
1-(5-Chloro-2-methoxyphenyl)-3-(2-methyl-4-quinolinyl)urea
1-(5-Chloro-2-Methoxyphenyl)-3-(2-Methylquinolin-4-yl)urea
N-(5-Chloro-2-methoxyphenyl)-N′-(2-methylquinolin-4-yl)urea
N-(5-Chloro-2-methoxyphenyl)-N'-(2-methyl-4-quinolinyl)urea
Urea, N-(5-chloro-2-Methoxyphenyl)-N'-(2-Methyl-4-quinolinyl)-
PQ 401
N-(5-Chloro-2-methoxyphenyl)-N'-(2-methyl-4-quinolinyl)-urea
IGF-1R Inhibitor II, N-(5-Chloro-2-methoxyphenyl)-Nμ-(2-methylquinolin-4-yl)urea
N-(5-Chloro-2-methoxyphenyl)-N'-(2-methyl-4-quinolinyl)-urea PQ401 | [Molecular Formula]
C18H16ClN3O2 | [MDL Number]
MFCD00160558 | [MOL File]
196868-63-0.mol | [Molecular Weight]
341.796 |
| Chemical Properties | Back Directory | [density ]
1.370±0.06 g/cm3 (20 ºC 760 Torr) | [storage temp. ]
2-8°C | [solubility ]
DMSO: >10mg/mL | [form ]
White solid | [color ]
white | [InChI]
InChI=1S/C18H16ClN3O2/c1-11-9-15(13-5-3-4-6-14(13)20-11)21-18(23)22-16-10-12(19)7-8-17(16)24-2/h3-10H,1-2H3,(H2,20,21,22,23) | [InChIKey]
YBLWOZUPHDKFOT-UHFFFAOYSA-N | [SMILES]
N(C1=CC(Cl)=CC=C1OC)C(NC1C2C(N=C(C)C=1)=CC=CC=2)=O |
| Safety Data | Back Directory | [Hazard Codes ]
T | [Risk Statements ]
25 | [Safety Statements ]
45 | [RIDADR ]
UN 2811 6.1/PG 3 | [WGK Germany ]
3 | [Storage Class]
11 - Combustible Solids |
| Hazard Information | Back Directory | [Uses]
Potent inhibitor of insulin-like growth factor I receptor (IGF-IR) signalling and breast cancer cell growth in culture and in vivo. | [Definition]
ChEBI: 1-(5-chloro-2-methoxyphenyl)-3-(2-methyl-4-quinolinyl)urea is a member of quinolines. | [Biological Activity]
Insulin-like growth factor receptor (IGF1R) inhibitor. Suppresses IGF-stimulated IGF-IR autophosphorylation with an IC 50 value of 12 μ M. Inhibits growth of MCF-7 breast cancer cells in vitro and in vivo . | [in vivo]
a treatment with pq401 triple per week reduced the growth rate of mcneua cells implanted into mice [1]. | [storage]
Store at +4°C | [References]
[1]. gable kl, maddux ba, penaranda c, zavodovskaya m, campbell mj, lobo m, robinson l, schow s, kerner ja, goldfine id, youngren jf. diarylureas are small-molecule inhibitors of insulin-like growth factor i receptor signaling and breast cancer cell growth. mol cancer ther. 2006 apr;5(4):1079-86.
[2]. wang h, qin j, gong s, feng b, zhang y, tao j. insulin-like growth factor-1 receptor-mediated inhibition of a-type k(+) current induces sensory neuronal hyperexcitability through the phosphatidylinositol 3-kinase and extracellular signal-regulated kinase 1/2 pathways, independently of akt. endocrinology. 2014 jan;155(1):168-79. |
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