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1969299-27-1

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1969299-27-1 Structure

1969299-27-1 Structure
IdentificationBack Directory
[Name]

Ald-benzyl-amide-PEG4-propargyl
[CAS]

1969299-27-1
[Synonyms]

Ald-Ph-amido-PEG4-propargyl
Ald-benzyl-amide-PEG4-propargyl
[Molecular Formula]

C19H25NO6
[MDL Number]

MFCD31715382
[MOL File]

1969299-27-1.mol
[Molecular Weight]

363.4
Chemical PropertiesBack Directory
[Boiling point ]

553.0±50.0 °C(Predicted)
[density ]

1.150±0.06 g/cm3(Predicted)
[pka]

13.53±0.46(Predicted)
Hazard InformationBack Directory
[Uses]

Ald-Ph-amido-PEG4-propargyl is a non-cleavable 4 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1]. Ald-Ph-amido-PEG4-propargyl is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
[IC 50]

Non-cleavable Linker
[References]

[1] Beck A, et al. Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug Discov. 2017 May;16(5):315-337. DOI:10.1038/nrd.2016.268
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