| Identification | Back Directory | [Name]
Cyclopropanecarboxamide, N-[5-[4-(cyanomethyl)-2-fluorophenyl]imidazo[1,2-a]pyridin-2-yl]- | [CAS]
1973485-06-1 | [Synonyms]
JAK-IN-14
Cyclopropanecarboxamide, N-[5-[4-(cyanomethyl)-2-fluorophenyl]imidazo[1,2-a]pyridin-2-yl]- | [Molecular Formula]
C19H15FN4O | [MOL File]
1973485-06-1.mol | [Molecular Weight]
334.35 |
| Chemical Properties | Back Directory | [density ]
1.38±0.1 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
DMSO : 10.5 mg/mL (31.40 mM; ultrasonic and warming and heat to 60°C) | [form ]
Solid | [pka]
10.54±0.50(Predicted) | [color ]
Off-white to light yellow |
| Hazard Information | Back Directory | [Biological Activity]
JAK-IN-14 is a potent and selective JAK1 inhibitor, with an IC50 of 8-fold more selective for JAK1 than JAK2 and JAK3 (Patent WO2016119700A1, compound 16)[1]. | [References]
[1]. Jin Li, et al. Substituted imidazo [1, 2-a] pyridin-2-ylamine compounds, and pharmaceutical compositions and methods of use thereof. WO2016119700A1. |
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