| Identification | Back Directory | [Name]
TFLLR-NH2 | [CAS]
197794-83-5 | [Synonyms]
TFLLR
TFLLR-NH2
TFLLR-AMIDE
TFLLR-NH2(2TFA)
(Thr1)-TRAP-5 amide
HYBRIDE HUMAN-XENOPE
THR-PHE-LEU-LEU-ARG-NH2
H-THR-PHE-LEU-LEU-ARG-NH2
(Thr1)-PAR-1 (1-5) amide (human)
REF DUPL: H-Thr-Phe-Leu-Leu-Arg-NH2
THROMBIN RECEPTOR (PAR-1), HYBRIDE HUMAN-XENOPE
TFLLR-NH2 Protease-Activated Receptor 1 (PAR1) Agonist
L-Argininamide, L-threonyl-L-phenylalanyl-L-leucyl-L-leucyl-
TFLLRaMide, (Thr1)-TRAP-5 aMide, (Thr1)-PAR-1 (1-5) aMide (huMan)
(2S)-N-[(2S)-1-[[(2S)-1-amino-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]-2-[[(2S)-2-[[(2S,3R)-2-amino-3-hydroxybutanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanamide | [Molecular Formula]
C31H53N9O6 | [MDL Number]
MFCD03093514 | [MOL File]
197794-83-5.mol | [Molecular Weight]
647.81 |
| Chemical Properties | Back Directory | [density ]
1.31±0.1 g/cm3(Predicted) | [storage temp. ]
Desiccate at -20°C | [form ]
Powder | [pka]
12.10±0.45(Predicted) | [Water Solubility ]
Soluble to 1 mg/ml in water | [Sequence]
Thr-Phe-Leu-Leu-Arg-NH2 |
| Hazard Information | Back Directory | [Uses]
TFLLR-NH2 is a PAR-1 activator. | [in vivo]
Injection of TF-NH2 into the rat paw stimulates a marked and sustained oedema. An NK1R antagonist and ablation of sensory nerves with capsaicin inhibit oedema by 44% at 1?h and completely by 5?h. In wild-type but not PAR1?/? mice, TF-NH2 stimulates Evans blue extravasation in the bladder, oesophagus, stomach, intestine and pancreas by 2–8 fold. Extravasation in the bladder, oesophagus and stomach is abolished by an NK1R antagonist[1]. TFp-NH2 produces notable contraction at 3-50 μM and relaxation at 0.3-50 μM, in the absence of apamin. The concentration-response curve for TFp-NH2-induced contraction is remarkably shifted left, when the TFp-NH2-induced relaxation is blocked by apamin at 0.1 μM[3]. | [IC 50]
PAR1: 1.9 μM (EC50) | [storage]
-20°C |
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