| Identification | Back Directory | [Name]
Apricoxib | [CAS]
197904-84-0 | [Synonyms]
TG 01
CS 706
R 109339
Apricoxib
Benzenesulfonamide, 4-[2-(4-ethoxyphenyl)-4-methyl-1H-pyrrol-1-yl]- | [Molecular Formula]
C19H20N2O3S | [MDL Number]
MFCD18633301 | [MOL File]
197904-84-0.mol | [Molecular Weight]
356.44 |
| Chemical Properties | Back Directory | [Melting point ]
148-151°C | [storage temp. ]
Refrigerator | [solubility ]
Chloroform (Slightly), Methanol (Slightly) | [form ]
Solid | [color ]
Yellow |
| Hazard Information | Back Directory | [Uses]
Apricoxib, is an orally active, selective COX-2 inhibitor, used as as an analgesic and anti-inflammatory agent, and also has anticancer potential, since COX-2 inhibition can reduce tumor growth and augment therapy.
| [Enzyme inhibitor]
This oral COX-2 inhibitor (FW = 356.44 g/mol; CAS 162011-90-7), also
named CS-706 and 4-[2- (4-ethoxyphenyl) -4-methyl-1H-pyrrol-1-yl]-
benzene sulfonamide, targets Cyclooxygenase-2, which is over-
expressed in advanced stage non-small-cell lung cancer (NSCLC), possibly
as a result of elevated levels of COX-2-dependent prostaglandin E2 (PGE2).
That said, a randomized, double-blind, placebo-controlled, multicenter
phase II study found little evidence of efficacy of apricoxib in
combination with either docetaxel or pemetrexed in patients with
biomarker-selected NSCLC. See also Rofecoxib |
|
| Company Name: |
BOC Sciences
|
| Tel: |
1-631-485-4226; 16314854226 |
| Website: |
https://www.bocsci.com |
| Company Name: |
NCE Biomedical Co.,Ltd.
|
| Tel: |
4000-027-021 |24 +86-13986109188 | +86-15623472865 | +81-08033611988 |
| Website: |
www.chemicalbook.com/ShowSupplierProductsList15748/0_EN.htm |
| Company Name: |
SPIRO PHARMA
|
| Tel: |
|
| Website: |
www.spiropharma.com.cn |
| Company Name: |
Energy Chemical
|
| Tel: |
021-58432009 400-005-6266 |
| Website: |
http://www.energy-chemical.com |
|