| Identification | Back Directory | [Name]
(2-amino-3-hydroxy-octadecoxy)phosphonic acid | [CAS]
19794-97-9 | [Synonyms]
2S-amino-1
SPHINGANINE-1-PHOSPHATE
dihydrosphingosine 1-phosphate
(2S,3R)-Sphinganine 1-Phosphate
Sphinganine-1-phosphate (d18:0)
D-erythro-sphinganine-1-phosphate
C18-Dihydrosphingosine 1-Phosphate
(2-amino-3-hydroxy-octadecoxy)phosphonic acid
(2S,3R)-2-AMino-1,3-octadecanediol 1-(Dihydrogen Phosphate)
[R-(R*,S*)]-2-AMino-1,3-octadecanediol 1-(Dihydrogen Phosphate)
1,3-Octadecanediol, 2-amino-, 1-(dihydrogen phosphate), (2S,3R)- | [Molecular Formula]
C18H40NO5P | [MOL File]
19794-97-9.mol | [Molecular Weight]
381.49 |
| Chemical Properties | Back Directory | [Boiling point ]
548.2±60.0 °C(Predicted) | [density ]
1.080±0.06 g/cm3(Predicted) | [storage temp. ]
-20°C | [solubility ]
0.3 M NaOH: 4 mg/ml; DMF: <50 μg/ml; DMSO: <50 μg/ml; Ethanol: <50 μg/ml; PBS (pH 7.2): <50 μg/ml | [form ]
A crystalline solid | [pka]
1.76±0.10(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Chemical Properties]
White to Beige Solid | [Uses]
(2-amino-3-hydroxy-octadecoxy)phosphonic acid may be used as a negative control for C2 Ceramide. | [Definition]
ChEBI: A sphingoid 1-phosphate that is the monophosphorylated derivative of sphinganine. | [Biochem/physiol Actions]
Negative control for sphingosine-1-phosphate. | [in vivo]
Sphinganine 1-phosphate can enhance wound healing in diabetic mice[1].
Sphinganine 1-phosphate provides renal and hepatic protection after liver ischemia and reperfusion (IR) injury in mice through selective activation of S1P1 receptors and pertussis toxin-sensitive G-proteins with subsequent activation of ERK and Akt. Sphinganine 1-phosphate (administered 0.1 mg/kg i.v. immediately before reperfusion and 0.2 mg/kg s.c. 2 h after reperfusion) protects against hepatic and renal injury after liver IR[2]. | Animal Model: | Male C57BL/6 mice (20-25?g)[2] | | Dosage: | 0.1?mg/kg | | Administration: | Administered i.v. immediately before reperfusion and 0.2?mg/kg s.c. 2 h after reperfusion | | Result: | The plasma level of alanine aminotransferase (ALT) and Creatinine (Cr) was 80±6 U/L and 0.46±0.05 mg/dL, respectively.
The increases in ALT (7474±557?U/L) and Cr (0.55±0.05?mg/dL) were significantly suppressed at 24?h after reperfusion in mice treated with 0.1?mg/kg i.v. before reperfusion and 0.2?mg/kg s.c. 2?h after reperfusion.
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| [IC 50]
Human Endogenous Metabolite |
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