| Identification | Back Directory | [Name]
Cyclopentanecarboxylic acid, 2-amino-4-methylene-, (1R,2S)- (9CI) | [CAS]
198022-65-0 | [Synonyms]
PLD118
PLD-118
PLD 118
BAY 108888
BAY 10-8888
Icofungipen
Cyclopentanecarboxylic acid, 2-amino-4-methylene-, (1R,2S)-
Cyclopentanecarboxylic acid, 2-amino-4-methylene-, (1R,2S)- (9CI) | [Molecular Formula]
C7H11NO2 | [MDL Number]
MFCD06202415 | [MOL File]
198022-65-0.mol | [Molecular Weight]
141.17 |
| Hazard Information | Back Directory | [Uses]
Icofungipen is an orally active antifungal agent. Icofungipen is the representative of beta amino acids, is toxic against Candida species. Icofungipen protects infected mice survival from C. albicans infection[1]. | [in vivo]
Icofungipen (5-25 mg/kg; po; twice daily for 7 days) shows a dose-dependent protection against clinical isolates of C. albicans in a lethal model of infection in mice[1].
| [References]
[1] Hasenoehrl A, et al. In vitro activity and in vivo efficacy of icofungipen (PLD-118), a novel oral antifungal agent, against the pathogenic yeast Candida albicans. Antimicrob Agents Chemother. 2006 Sep;50(9):3011-8. DOI:10.1128/AAC.00254-06 |
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