| Identification | Back Directory | [Name]
R-(+)-LISURIDE HYDROGEN MALEATE | [CAS]
19875-60-6 | [Synonyms]
Apodel
Revanil
cuvalit
lysenyl
Dopergin
lisuridemaleate
lysenylbimaleate
Lysuride maleate
lysenylhydrogenmaleate
lisuridehydrogenmaleate
R-(+)-LISURIDE HYDROGEN MALEATE
N'-[(8α)-9,10-Didehydro-6-methylergolin-8-yl]-N,N-diethylureamaleate
3-(9,10-didehydro-6-methylergolin-8-yl)-1,1-diethylureahydrogenmaleate
3-(9,10-didehydro-6-methylergolin-8-alpha-yl)-1,1-diethylureamaleate(1:1)
3-(9,10-didehydro-6-methylergolin-8-alpha-yl)-1,1-diethyl-uremaleate(1:1)
1-((5r,8s)-6-methyl-9,10-didehydro-8-ergolinyl)-3,3-diethylureahydrogenmale
Urea, 3-(9,10-didehydro-6-methylergolin-8a-yl)-1,1-diethyl-, maleate (1:1) (8CI)
N'-(9,10-Didehydro-6-methylergoline-8α-yl)-N,N-diethylurea·(Z)-2-butenedioic acid
Urea, N'-[(8a)-9,10-didehydro-6-methylergolin-8-yl]-N,N-diethyl-, (Z)-2-butenedioate (1:1)
Urea, N'-[(8a)-9,10-didehydro-6-methylergolin-8-yl]-N,N-diethyl-, (2Z)-2-butenedioate (1:1) (9CI) | [EINECS(EC#)]
243-387-3 | [Molecular Formula]
C24H30N4O5 | [MDL Number]
MFCD28166478 | [MOL File]
19875-60-6.mol | [Molecular Weight]
454.52 |
| Chemical Properties | Back Directory | [Melting point ]
200° (dec) | [alpha ]
D20 +288° (c = 0.5 in methanol) | [storage temp. ]
Desiccate at RT | [solubility ]
DMSO:34.83(Max Conc. mg/mL);76.63(Max Conc. mM) | [form ]
Solid | [color ]
Off-White to Light Yellow | [Stability:]
Hygroscopic |
| Hazard Information | Back Directory | [Uses]
Lisuride Maleate is a dopamine receptor agonist with additionally serotoninergic, adrenergic, and glutamate antagonistic properties. Treatment of Parkinsonism and other diseases associated with high level of prolactin. | [in vivo]
Lisuride (maleate) (0.78 and 3.13 mg/kg; i.p.; p.o.) is 3-4 times more potent on i.p. than on p.o. [2].
Lisuride (maleate) (0.78-3.13 mg/kg; i.p.) antagonizes the motor depression and hypothermia induced by reserpine[2].
Lisuride (maleate) (0.78-3.13 mg/kg; i.p.) is about as effective as apomorphine and D-amphetamine and causes significant hypothermia measured after dosages as low as 0.10 mg/kg i.p.[2]. | Animal Model: | NMRI mice (18-25 g)[2] | | Dosage: | 0.78 and 3.13 mg/kg | | Administration: | i.p., p.o. | | Result: | Been 3-4 times more potent on i.p. than on p.o.. |
| [storage]
Store at RT |
|
| Company Name: |
Energy Chemical
|
| Tel: |
021-58432009 400-005-6266 |
| Website: |
http://www.energy-chemical.com |
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