| Chemical Properties | Back Directory | [Boiling point ]
809.2±65.0 °C(Predicted) | [density ]
1.25±0.1 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
DMF: soluble; DMSO: soluble; Ethanol: soluble; Methanol: soluble | [form ]
A solid | [pka]
12.43±0.70(Predicted) |
| Hazard Information | Back Directory | [Description]
Doramectin aglycone is an acid degradation product of doramectin , a disaccharide-containing anthelmintic that potentiates glutamate- and GABA-gated chloride channel opening in nematodes, and its acid-catalyzed hydrolysis product doramectin monosaccharide . Doramectin undergoes one round of acid-catalyzed hydrolysis to form doramectin monosaccharide which is then hydrolyzed again to remove the remaining saccharide unit and form doramectin aglycone. | [Uses]
Doramectin aglycone is an acid degradation product produced by hydrolysis of the disaccharide unit of doramectin. Doramectin aglycone is an inhibitor of nematode larval development, but is devoid of paralytic activity. Despite the importance of doramectin as an anthelmintic in animal health, there are no published reports of the biological activity or the levels of doramectin aglycone in animals or in the environment. | [References]
[1] BO HONG. Prodigiosin rescues deficient p53 signaling and antitumor effects via upregulating p73 and disrupting its interaction with mutant p53.[J]. Cancer research, 2014, 74 4: 1153-1165. DOI: 10.1158/0008-5472.can-13-0955
[2] ALEXANDER F. MOORE . Primary pH degradation products of doramectin[J]. Tetrahedron Letters, 2016, 57 37: Pages 4224-4227. DOI: 10.1016/j.tetlet.2016.08.014 |
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