| Identification | Back Directory | [Name]
1-Pyrrolidinecarboxylicacid,3-(methylamino)-,1,1-dimethylethylester,(R)-(9CI) | [CAS]
199336-83-9 | [Synonyms]
1-N-Boc-3-(R)-(Methylamino) pyrrolidine
(R)-1-Boc-3-(methylamino)pyrrolidine HCl
(S)-1-Boc-3-methylaminopyrrolidine, hydrochloride
(R)-1-Boc-3-(Methylamino)pyrrolidinehydrochloride
(R)-benzyl 3-(methylamino)pyrrolidine-1-carboxylate
2-Methyl-2-propanyl methyl(3-pyrrolidinyl)carbamate
ert-butyl(3R)-3-(methylamino)pyrrolidine-1-carboxylate
tert-butyl (R)-3-(methylamino)pyrrolidine-1-carboxylate
tert-Butyl (3R)-3-(methylamino)pyrrolidine-1-carboxylate
(R)-3-(Methylamino)pyrrolidine-1-carboxylic acid tert-butyl ester
1-Pyrrolidinecarboxylicacid,3-(MethylaMino)-,1,1-diMethylethylester,(3R)-
1-Pyrrolidinecarboxylicacid,3-(methylamino)-,1,1-dimethylethylester,(R)-(9CI)
1-Pyrrolidinecarboxylicacid,3-(methylamino)-,1,1-dimethylethylester,(R)-(9CI) USP/EP/BP | [Molecular Formula]
C10H20N2O2 | [MDL Number]
MFCD09752961 | [MOL File]
199336-83-9.mol | [Molecular Weight]
200.28 |
| Chemical Properties | Back Directory | [Boiling point ]
269 ºC | [density ]
1.03 | [Fp ]
117 ºC | [storage temp. ]
Keep in dark place,Inert atmosphere,2-8°C | [pka]
10.02±0.20(Predicted) | [Appearance]
Colorless to light yellow Liquid |
| Questions And Answer | Back Directory | [Application]
(R)-3-(methylamino)pyrrolidine-1-carboxylic acid tert-butyl ester can be used as an organic synthesis intermediate and a pharmaceutical intermediate, mainly in laboratory research and development processes and chemical production processes. |
| Hazard Information | Back Directory | [Synthesis]
Step 7-2: 1.18 g of (R)-1-(tert-butoxycarbonyl)-3-methylaminopyrrolidine hydrochloride (chemical purity: 99.9 area%) was mixed with 2.30 g of 23 wt. % brine, 4.71 g of toluene and 734 mg of 30 wt. % aqueous sodium hydroxide solution, and was prepared in accordance with the methodology described in Step 7-1. After stirring the reaction mixture, a partitioning operation was carried out. The organic layer was concentrated and dried under vacuum to give 946 mg of tert-butyl (R)-3-(methylamino)pyrrolidine-1-carboxylate as a colorless, transparent liquid (chemical purity: 99.3 area%, yield 97%).1H-NMR (CDCl3) data: δ (ppm) 1.45 (s, 9H), 1.71 (m, 2H), 2.04 (m, 1H). 2.44 (s, 3H), 3.03-3.28 (m, 2H), 3.29-3.65 (m, 3H). | [References]
[1] Patent: EP2050735, 2009, A1. Location in patent: Page/Page column 20 |
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| Company Name: |
Energy Chemical
|
| Telephone: |
400-0056266 |
| Website: |
www.energy-chemical.com |
| Company Name: |
China Langchem Inc.
|
| Telephone: |
0086-21-58956006 |
| Website: |
www.chemicalbook.com/ShowSupplierProductsList19141/0_EN.htm |
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