| Identification | Back Directory | [Name]
ELOCALCITOL | [CAS]
199798-84-0 | [Synonyms]
BXL 628
Ro 26-9228
ELOCALCITOL
Ellocalciferol
(1R,3E,5S)-3-[(2E)-2-[(3aS,7aS)-1-[(E,2S)-6-ethyl-6-hydroxyoct-4-en-2-yl]-7a-methyl-3a,5,6,7-tetrahydro-3H-inden-4-ylidene]ethylidene]-5-fluoro-4-methylidenecyclohexan-1-ol
Cyclohexanol, 3-[(2E)-2-[(3aS,7aS)-1-[(1S,3E)-5-ethyl-5-hydroxy-1-methyl-3-hepten-1-yl]-3,3a,5,6,7,7a-hexahydro-7a-methyl-4H-inden-4-ylidene]ethylidene]-5-fluoro-4-methylene-, (1R,3Z,5S)- | [Molecular Formula]
C29H43FO2 | [MDL Number]
MFCD09954119 | [MOL File]
199798-84-0.mol | [Molecular Weight]
442.65 |
| Chemical Properties | Back Directory | [Boiling point ]
568.3±50.0 °C(Predicted) | [density ]
1.05±0.1 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
Ethanol:20.0(Max Conc. mg/mL);45.18(Max Conc. mM) | [form ]
A crystalline solid | [pka]
14.04±0.40(Predicted) | [color ]
White to off-white | [Optical Rotation]
[α]/D +97 to +107°, c =c=1 in methanol | [InChIKey]
LRLWXBHFPGSUOX-GJQYOBCGSA-N | [SMILES]
F[C@H]1C[C@@H](C\C(=C\C=C2\[C@H]3[C@](CCC\2)(C(=CC3)[C@H](C\C=C\C(O)(CC)CC)C)C)\C1=C)O |
| Hazard Information | Back Directory | [Description]
BXL-628 is an analog of vitamin D3 that has diverse biological activities. It increases death of androgen-stimulated human benign prostatic hyperplasia (BPH) cells via induction of apoptosis in a dose-dependent manner. In vivo, BXL-628 completely inhibits androgen-stimulated prostate overgrowth in a rat model of BPH. It reduces expression of IL-13 and IgE/mast cell-derived protease 1 (MMCP1) and decreases edema and leukocyte infiltration in the bladder wall in a mouse model of allergen-induced interstitial cystitis. BXL-628 also reduces the number of adherent endometrial stromal cells and decreases the total weight of endometrial lesions in a mouse model of endometriosis. Formulations containing BXL-628 are under clinical investigation for the treatment of BPH. | [Uses]
Elocalcitol (BXL-628) is a selective, orally active vitamin D receptor (VDR) agonist. Elocalcitol shows anti-inflammatory activity. Elocalcitol inhibits growth of prostate cancer cells[1][2]. | [References]
[1] Mariani M, et al. The selective vitamin D receptor agonist, elocalcitol, reduces endometriosis development in a mouse model by inhibiting peritoneal inflammation. Hum Reprod. 2012 Jul;27(7):2010-9. DOI:10.1093/humrep/des150
[2] Marchiani S, et al. The vitamin D analogue BXL-628 inhibits growth factor-stimulated proliferation and invasion of DU145 prostate cancer cells. J Cancer Res Clin Oncol. 2006 Jun;132(6):408-16. DOI:10.1007/s00432-006-0086-8 |
|
| Company Name: |
LGM Pharma
|
| Tel: |
1-(800)-881-8210 |
| Website: |
www.lgmpharma.com |
|