Identification | Back Directory | [Name]
7-Cyano-7-deaza-2'-deoxy guanosine | [CAS]
199859-58-0 | [Synonyms]
7-Cyano-7-deaza-2'-deoxy guanosine 2-Amino-7-(2-deoxy--D-ribofuranosyl)-5-cyano-7H-pyrrolo[2,3-d]pyrimidin-4(3H)-one 3H-Pyrrolo[2,3-d]pyrimidine-5-carbonitrile, 2-amino-7-(2-deoxy-β-D-erythro-pentofuranosyl)-4,7-dihydro-4-oxo- | [Molecular Formula]
C12H13N5O4 | [MDL Number]
MFCD31697574 | [MOL File]
199859-58-0.mol | [Molecular Weight]
291.27 |
Hazard Information | Back Directory | [Uses]
7-Cyano-7-deaza-2'-deoxy guanosine is a guanosine analog. Some guanosine analogs have immunostimulatory activity. In some animal models, they also induce type I interferons, producing antiviral effects. Studies have shown that the functional activity of guanosine analogs is dependent on the activation of Toll-like receptor 7 (TLR7)[1]. | [References]
[1] Lee J, et al. Molecular basis for the immunostimulatory activity of guanine nucleoside analogs: activation of Toll-like receptor 7. Proc Natl Acad Sci U S A. 2003 May 27;100(11):6646-51. DOI:10.1073/pnas.0631696100 |
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