| Identification | Back Directory | [Name]
SKF-38393 (hydrobromide) | [CAS]
20012-10-6 | [Synonyms]
SKF-38393 HBr
SKF 38393;SKF38393;SKF-38393
5-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine-7,8-diol:hydrobromide | [Molecular Formula]
C16H18BrNO2 | [MDL Number]
MFCD06407975 | [MOL File]
20012-10-6.mol | [Molecular Weight]
336.23 |
| Chemical Properties | Back Directory | [Melting point ]
283-285 °C | [storage temp. ]
Desiccate at -20°C | [solubility ]
Soluble to 25 mM in water with gentle warming and to 25 mM in ethanol with gentle warming | [form ]
Powder | [color ]
White |
| Hazard Information | Back Directory | [Uses]
SKF 38393 Hydrobromide is a derivative of a unique dopamine receptor agonist. | [in vivo]
SKF 38393 hydrobromide (10 mg/kg; i.p.) blocks the 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) -induced depletion of glutathione[3].
SKF 38393 hydrobromide attenuates MPTP-induced depletion of dopamine[3].
SKF 38393 hydrobromide enhances the activity of superoxide dismutase and hence mimics the action of Selegiline[3].
SKF 38393 hydrobromide enhances the frequency but not the amplitude of tetrodotoxin-resistant excitatory postsynaptic currents which argues for a presynaptic locus of D1 action[4].
| Animal Model: | Balb/c mice (20-25 g)[3] | | Dosage: | 5 mg/kg, 10 mg/kg | | Administration: | Intraperitoneal injection | | Result: | Blocked the MPTP-induced depletion of glutathione and attenuated MPTP-induced depletion of dopamine. |
| [IC 50]
D1 Receptor: 110 nM (IC50) | [storage]
-20°C (desiccate) |
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| Company Name: |
BOC Sciences
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| Tel: |
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| Website: |
https://www.bocsci.com |
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