| Identification | Back Directory | [Name]
2,3-DIBROMO-5-ETHOXY-6-HYDROXYBENZALDEHYDE | [CAS]
20041-64-9 | [Synonyms]
AKOS BB-7665
ASISCHEM B65315
5,6-Dibromo-o-bourbonal
3-Ethoxy-5,6-dibromosalicylaldehyde
2,3-DIBROMO-5-ETHOXY-6-HYDROXYBENZALDEHYDE
Benzaldehyde, 2,3-dibromo-5-ethoxy-6-hydroxy-
3-Ethoxy-5,6-dibromosalicylaldehyde >=95% (HPLC) | [Molecular Formula]
C9H8Br2O3 | [MDL Number]
MFCD00297095 | [MOL File]
20041-64-9.mol | [Molecular Weight]
323.97 |
| Chemical Properties | Back Directory | [Boiling point ]
336.0±37.0 °C(Predicted) | [density ]
1.879±0.06 g/cm3(Predicted) | [storage temp. ]
2-8°C | [solubility ]
DMSO: ≥15mg/mL | [form ]
powder | [pka]
6.79±0.28(Predicted) | [color ]
yellow | [InChI]
1S/C9H8Br2O3/c1-2-14-7-3-6(10)8(11)5(4-12)9(7)13/h3-4,13H,2H2,1H3 | [InChIKey]
MZAISYPWQNBWED-UHFFFAOYSA-N | [SMILES]
CCOc1cc(Br)c(Br)c(C=O)c1O |
| Hazard Information | Back Directory | [Uses]
3-Ethoxy-5,6-dibromosalicylaldehyde was used to study modulation of autophagy, JNK activation and NF-KB-mediated inflammation. | [Biological Activity]
3-Ethoxy-5,6-dibromosalicylaldehyde is a non-competitive inhibitor of Inositol-requiring enzyme 1 (IRE1). It inhibits XBP-1 splicing induced pharmacologically in human cells. 3-Ethoxy-5,6-dibromosalicylaldehyde potently inhibits the endoribonuclease of IRE1 but does not inhibit RNases AT1or L. |
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Energy Chemical
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Merck KGaA
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AsisChem, Inc.
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