| Identification | Back Directory | [Name]
N-[2-[6-[(2-Ethyl-5,7-dimethyl-3H-imidazo[4,5-b]pyridin-3-yl)methyl]-2-quinolinyl]phenyl]-1,1,1-trifluoromethanesulfonamide | [CAS]
200639-61-8 | [Synonyms]
| [Molecular Formula]
C27H24F3N5O2S | [MOL File]
200639-61-8.mol | [Molecular Weight]
539.57 |
| Chemical Properties | Back Directory | [Melting point ]
252.0 °C | [Boiling point ]
691.6±65.0 °C(Predicted) | [density ]
1.40±0.1 g/cm3(Temp: 20 °C; Press: 760 Torr)(Predicted) | [pka]
2.35±0.10(Predicted) |
| Hazard Information | Back Directory | [Uses]
GA 0113 is a potent and orally active angiotensin II (Ang II) AT1-receptor antagonist. GA 0113 inhibits the Ang II (HY-13948)-induced pressor response with ID50 of 0.032 mg/kg and dose-dependently increases plasma renin activity for 48 h[1]. | [References]
[1] Ebisu H, et al. Pharmacologic profiles of GA0113, a novel quinoline derivative angiotensin II AT1-receptor antagonist. J Cardiovasc Pharmacol. 1999 Oct;34(4):526-32. DOI:10.1097/00005344-199910000-00008 |
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