| Identification | Back Directory | [Name]
Diosbulbin C | [CAS]
20086-07-1 | [Synonyms]
Diosbulbin C
Airpotato yam C
4H-3a,6-Methanofuro[2,3-d][2]benzoxepin-7-carboxylic acid, 2-(3-furanyl)decahydro-9-hydroxy-10b-methyl-4-oxo-, (2R,3aS,6S,6aS,7R,9R,10aR,10bS)-
(2R)-2-(3-Furyl)-1,2,6,6aβ,7,8,9,10,10aα,10b-decahydro-9α-hydroxy-10bβ-methyl-4-oxo-4H-3aβ,6β-methanofuro[2,3-d][2]benzoxepine-7α-carboxylic acid | [Molecular Formula]
C19H22O7 | [MDL Number]
MFCD20260750 | [MOL File]
20086-07-1.mol | [Molecular Weight]
362.37 |
| Chemical Properties | Back Directory | [Melting point ]
247-250 °C | [Boiling point ]
606.0±55.0 °C(Predicted) | [density ]
1.46±0.1 g/cm3(Predicted) | [solubility ]
Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc. | [form ]
Powder | [pka]
4.36±0.70(Predicted) |
| Hazard Information | Back Directory | [Uses]
Diosbulbin C is a diterpene lactone component, which can be extracted from traditional Chinese medicine Dioscorea bulbifera L.. Diosbulbin C possesses high anticancer activity in non-small cell lung cancer (NSCLC). Diosbulbin C could induce cell cycle arrest at G0/G1 phase in NSCLC. Diosbulbin C also inhibits the proliferation of NSCLC cells, possibly by downregulating the expression/activation of AKT, DHFR, and TYMS[1][1]. | [Definition]
ChEBI: Diosbulbin C is a naphthofuran. | [References]
[1] Zhu Z, et al. Diosbulbin C, a novel active ingredient in Dioscorea bulbifera L. extract, inhibits lung cancer cell proliferation by inducing G0/G1 phase cell cycle arrest. BMC Complement Med Ther. 2023 Dec 4;23(1):436. DOI:10.1186/s12906-023-04245-9 |
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